| Title |
Mapping the contribution of β3-containing GABAA receptors to volatile and intravenous general anesthetic actions
|
|---|---|
| Published in |
BMC Pharmacology, February 2007
|
| DOI | 10.1186/1471-2210-7-2 |
| Pubmed ID | |
| Authors |
Anja Zeller, Margarete Arras, Rachel Jurd, Uwe Rudolph |
| Abstract |
Agents belonging to diverse chemical classes are used clinically as general anesthetics. The molecular targets mediating their actions are however still only poorly defined. Both chemical diversity and substantial differences in the clinical actions of general anesthetics suggest that general anesthetic agents may have distinct pharmacological targets. It was demonstrated previously that the immobilizing action of etomidate and propofol is completely, and the immobilizing action of isoflurane partly mediated, by beta3-containing GABAA receptors. This was determined by using the beta3(N265M) mice, which carry a point mutation known to decrease the actions of general anesthetics at recombinant GABAA receptors. In this communication, we analyzed the contribution of beta3-containing GABAA receptors to the pharmacological actions of isoflurane, etomidate and propofol by means of beta3(N265M) mice. |
Mendeley readers
The data shown below were compiled from readership statistics for 35 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 2 | 6% |
| Unknown | 33 | 94% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Researcher | 9 | 26% |
| Student > Bachelor | 6 | 17% |
| Student > Ph. D. Student | 6 | 17% |
| Professor | 2 | 6% |
| Professor > Associate Professor | 2 | 6% |
| Other | 4 | 11% |
| Unknown | 6 | 17% |
| Readers by discipline | Count | As % |
|---|---|---|
| Medicine and Dentistry | 8 | 23% |
| Agricultural and Biological Sciences | 7 | 20% |
| Neuroscience | 6 | 17% |
| Pharmacology, Toxicology and Pharmaceutical Science | 2 | 6% |
| Chemistry | 2 | 6% |
| Other | 5 | 14% |
| Unknown | 5 | 14% |
Attention Score in Context
This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 13 April 2007.
All research outputs
#15,233,109
of 22,649,029 outputs
Outputs from BMC Pharmacology
#54
of 63 outputs
Outputs of similar age
#66,219
of 75,925 outputs
Outputs of similar age from BMC Pharmacology
#1
of 1 outputs
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