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Mendeley readers
Attention Score in Context
| Title |
Humanization of autoantigen
|
|---|---|
| Published in |
Nature Medicine, February 2007
|
| DOI | 10.1038/nm1496 |
| Pubmed ID | |
| Authors |
Wataru Nishie, Daisuke Sawamura, Maki Goto, Kei Ito, Akihiko Shibaki, James R McMillan, Kaori Sakai, Hideki Nakamura, Edit Olasz, Kim B Yancey, Masashi Akiyama, Hiroshi Shimizu |
| Abstract |
Transmissibility of characteristic lesions to experimental animals may help us understand the pathomechanism of human autoimmune disease. Here we show that human autoimmune disease can be reproduced using genetically engineered model mice. Bullous pemphigoid (BP) is the most common serious autoimmune blistering skin disease, with a considerable body of indirect evidence indicating that the underlying autoantigen is collagen XVII (COL17). Passive transfer of human BP autoantibodies into mice does not induce skin lesions, probably because of differences between humans and mice in the amino acid sequence of the COL17 pathogenic epitope. We injected human BP autoantibody into Col17-knockout mice rescued by the human ortholog. This resulted in BP-like skin lesions and a human disease phenotype. Humanization of autoantigens is a new approach to the study of human autoimmune diseases. |
Mendeley readers
The data shown below were compiled from readership statistics for 101 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United Kingdom | 1 | <1% |
| Italy | 1 | <1% |
| Austria | 1 | <1% |
| Unknown | 98 | 97% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Researcher | 23 | 23% |
| Student > Ph. D. Student | 21 | 21% |
| Student > Bachelor | 9 | 9% |
| Other | 6 | 6% |
| Student > Master | 6 | 6% |
| Other | 14 | 14% |
| Unknown | 22 | 22% |
| Readers by discipline | Count | As % |
|---|---|---|
| Medicine and Dentistry | 27 | 27% |
| Agricultural and Biological Sciences | 17 | 17% |
| Biochemistry, Genetics and Molecular Biology | 15 | 15% |
| Immunology and Microbiology | 8 | 8% |
| Unspecified | 1 | <1% |
| Other | 2 | 2% |
| Unknown | 31 | 31% |
Attention Score in Context
This research output has an Altmetric Attention Score of 4. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 31 January 2013.
All research outputs
#6,373,258
of 22,649,029 outputs
Outputs from Nature Medicine
#6,258
of 8,448 outputs
Outputs of similar age
#24,154
of 76,000 outputs
Outputs of similar age from Nature Medicine
#41
of 62 outputs
Altmetric has tracked 22,649,029 research outputs across all sources so far. This one has received more attention than most of these and is in the 70th percentile.
So far Altmetric has tracked 8,448 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 96.1. This one is in the 24th percentile – i.e., 24% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 76,000 tracked outputs that were published within six weeks on either side of this one in any source. This one has gotten more attention than average, scoring higher than 66% of its contemporaries.
We're also able to compare this research output to 62 others from the same source and published within six weeks on either side of this one. This one is in the 29th percentile – i.e., 29% of its contemporaries scored the same or lower than it.