| Title |
Therapeutic Drug Monitoring in Inflammatory Bowel Disease: Current State and Future Perspectives
|
|---|---|
| Published in |
Current Gastroenterology Reports, March 2014
|
| DOI | 10.1007/s11894-014-0378-0 |
| Pubmed ID | |
| Authors |
Niels Vande Casteele, Brian G. Feagan, Ann Gils, Séverine Vermeire, Reena Khanna, William J. Sandborn, Barrett G. Levesque |
| Abstract |
Current available anti-inflammatory drugs, in particular monoclonal antibodies directed against the cytokine tumor necrosis factor α (TNF), have greatly enhanced the treatment of inflammatory bowel diseases (IBD). Although many patients respond to ant-TNF therapy, a proportion of patients will not respond (primary non-response) or will lose response to the drug over time (secondary non-response). This loss of response can be caused by patient, TNF-inhibitor, or disease-related factors influencing the pharmacokinetics and pharmacodynamics of the drug. Therefore, monitoring pharmacological parameters (i.e. therapeutic drug monitoring) may help guide therapeutic decisions. This review emphasizes interesting and important new findings, and provides an updated overview, on the subject of therapeutic drug monitoring. While exploring the hypothesis that "one size does not fit all", we focused on the first prospective studies investigating the novel approach in IBD of 'target concentration adjusted dosing' and personalized medicine. |
X Demographics
The data shown below were collected from the profile of 1 X user who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Spain | 1 | 100% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 1 | 100% |
Mendeley readers
The data shown below were compiled from readership statistics for 108 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United Kingdom | 1 | <1% |
| Italy | 1 | <1% |
| Unknown | 106 | 98% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 23 | 21% |
| Researcher | 15 | 14% |
| Student > Master | 13 | 12% |
| Student > Bachelor | 13 | 12% |
| Student > Postgraduate | 9 | 8% |
| Other | 26 | 24% |
| Unknown | 9 | 8% |
| Readers by discipline | Count | As % |
|---|---|---|
| Medicine and Dentistry | 48 | 44% |
| Agricultural and Biological Sciences | 14 | 13% |
| Pharmacology, Toxicology and Pharmaceutical Science | 9 | 8% |
| Biochemistry, Genetics and Molecular Biology | 5 | 5% |
| Computer Science | 4 | 4% |
| Other | 15 | 14% |
| Unknown | 13 | 12% |
Attention Score in Context
This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 30 April 2014.
All research outputs
#20,723,696
of 25,457,297 outputs
Outputs from Current Gastroenterology Reports
#3
of 3 outputs
Outputs of similar age
#174,277
of 236,041 outputs
Outputs of similar age from Current Gastroenterology Reports
#1
of 1 outputs
Altmetric has tracked 25,457,297 research outputs across all sources so far. This one is in the 10th percentile – i.e., 10% of other outputs scored the same or lower than it.
So far Altmetric has tracked 3 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 25.9. This one scored the same or higher as 0 of them.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 236,041 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 12th percentile – i.e., 12% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 1 others from the same source and published within six weeks on either side of this one. This one has scored higher than all of them