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Mendeley readers
Attention Score in Context
| Title |
Environmental signals regulate lineage choice and temporal maturation of neural stem cells from human embryonic stem cells
|
|---|---|
| Published in |
Brain, April 2007
|
| DOI | 10.1093/brain/awm070 |
| Pubmed ID | |
| Authors |
A. J. Joannides, D. J. Webber, O. Raineteau, C. Kelly, K.-A. Irvine, C. Watts, A. E. Rosser, P. J. Kemp, W. F. Blakemore, A. Compston, M. A. Caldwell, N. D. Allen, S. Chandran |
| Abstract |
Human embryonic stem cells (hESCs) are a potential source of defined tissue for cell-based therapies in regenerative neurology. In order for this potential to be realized, there is a need for the evaluation of the behaviour of human embryonic stem cell-derived neural stem cells (hES-NSCs) both in the normal and the injured CNS. Using normal tissue and two experimental models, we examined the response of clinically compatible hES-NSCs to physiological and pathological signals. We demonstrate that the phenotypic potential of a multipotent population of hES-NSCs is influenced by these cues both in vitro and in vivo. hES-NSCs display a temporal profile of neurogenic and gliogenic differentiation, with the generation of mature neurons and glia over 4 weeks in vitro, and 20 weeks in the uninjured rodent brain. However, transplantation into the pathological CNS accelerates maturation and polarizes hES-NSC differentiation potential. This study highlights the role of environmental signals in determining both lineage commitment and temporal maturation of human neural stem cells. Controlled manipulation of environmental signals appropriate to the pathological specificity of the targeted disease will be necessary in the design of therapeutic stem cell-based strategies. |
Mendeley readers
The data shown below were compiled from readership statistics for 75 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Sweden | 2 | 3% |
| Germany | 1 | 1% |
| Switzerland | 1 | 1% |
| Brazil | 1 | 1% |
| Israel | 1 | 1% |
| Czechia | 1 | 1% |
| United Kingdom | 1 | 1% |
| Unknown | 67 | 89% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Researcher | 23 | 31% |
| Student > Ph. D. Student | 12 | 16% |
| Professor | 8 | 11% |
| Professor > Associate Professor | 8 | 11% |
| Student > Master | 7 | 9% |
| Other | 11 | 15% |
| Unknown | 6 | 8% |
| Readers by discipline | Count | As % |
|---|---|---|
| Agricultural and Biological Sciences | 31 | 41% |
| Medicine and Dentistry | 12 | 16% |
| Neuroscience | 11 | 15% |
| Biochemistry, Genetics and Molecular Biology | 7 | 9% |
| Psychology | 1 | 1% |
| Other | 1 | 1% |
| Unknown | 12 | 16% |
Attention Score in Context
This research output has an Altmetric Attention Score of 4. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 17 December 2013.
All research outputs
#6,373,258
of 22,649,029 outputs
Outputs from Brain
#4,160
of 7,072 outputs
Outputs of similar age
#24,017
of 76,491 outputs
Outputs of similar age from Brain
#31
of 59 outputs
Altmetric has tracked 22,649,029 research outputs across all sources so far. This one has received more attention than most of these and is in the 70th percentile.
So far Altmetric has tracked 7,072 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 25.2. This one is in the 39th percentile – i.e., 39% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 76,491 tracked outputs that were published within six weeks on either side of this one in any source. This one has gotten more attention than average, scoring higher than 66% of its contemporaries.
We're also able to compare this research output to 59 others from the same source and published within six weeks on either side of this one. This one is in the 44th percentile – i.e., 44% of its contemporaries scored the same or lower than it.