| Title |
Cognitive lifestyle jointly predicts longitudinal cognitive decline and mortality risk
|
|---|---|
| Published in |
European Journal of Epidemiology, February 2014
|
| DOI | 10.1007/s10654-014-9881-8 |
| Pubmed ID | |
| Authors |
Riccardo E. Marioni, Cecile Proust-Lima, Helene Amieva, Carol Brayne, Fiona E. Matthews, Jean-Francois Dartigues, Helene Jacqmin-Gadda |
| Abstract |
Cognitive lifestyle measures such as education, occupation, and social engagement are commonly associated with late-life cognitive ability although their associations with cognitive decline tend to be mixed. However, longitudinal analyses of cognition rarely account for death and dropout, measurement error of the cognitive phenotype, and differing trajectories for different population sub-groups. This paper applies a joint latent class mixed model (and a multi-state model in a sensitivity analysis) that accounts for these issues to a large (n = 3,653), population-based cohort, Paquid, to model the relationship between cognitive lifestyle and cognitive decline. Cognition was assessed over a 20-year period using the Mini-Mental State Examination. Three cognitive lifestyle variables were assessed: education, mid-life occupation, and late-life social engagement. The analysis identified four latent sub-populations with class-specific longitudinal cognitive decline and mortality risk. Irrespective of the cognitive trajectory, increased social engagement was associated with a decreased mortality risk. High education was associated with the most favourable cognitive trajectory, and after adjusting for cognitive decline, with an increased mortality risk. Mid-life occupational complexity was also associated with more favourable trajectories but not with mortality risk. To realistically examine the link between cognitive lifestyle and cognitive decline, complex statistical models are required. This paper applies and compares in a sensitivity analysis two such models, and shows education to be linked to a compression of cognitive morbidity irrespective of cognitive trajectory. Furthermore, a potentially modifiable variable, late-life social engagement is associated with a decreased mortality risk in all of the population sub-groups. |
X Demographics
The data shown below were collected from the profiles of 3 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United Kingdom | 1 | 33% |
| United States | 1 | 33% |
| Unknown | 1 | 33% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 3 | 100% |
Mendeley readers
The data shown below were compiled from readership statistics for 111 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United Kingdom | 1 | <1% |
| Japan | 1 | <1% |
| Vietnam | 1 | <1% |
| Unknown | 108 | 97% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Researcher | 21 | 19% |
| Student > Ph. D. Student | 15 | 14% |
| Student > Bachelor | 14 | 13% |
| Student > Master | 9 | 8% |
| Student > Doctoral Student | 8 | 7% |
| Other | 19 | 17% |
| Unknown | 25 | 23% |
| Readers by discipline | Count | As % |
|---|---|---|
| Medicine and Dentistry | 23 | 21% |
| Psychology | 19 | 17% |
| Social Sciences | 12 | 11% |
| Nursing and Health Professions | 9 | 8% |
| Neuroscience | 5 | 5% |
| Other | 15 | 14% |
| Unknown | 28 | 25% |
Attention Score in Context
This research output has an Altmetric Attention Score of 2. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 16 July 2014.
All research outputs
#16,164,559
of 25,547,904 outputs
Outputs from European Journal of Epidemiology
#1,430
of 1,811 outputs
Outputs of similar age
#129,434
of 235,987 outputs
Outputs of similar age from European Journal of Epidemiology
#13
of 14 outputs
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