Chapter title |
Taurine and Its Neuroprotective Role
|
---|---|
Chapter number | 2 |
Book title |
Taurine 8
|
Published in |
Advances in experimental medicine and biology, January 2013
|
DOI | 10.1007/978-1-4614-6130-2_2 |
Pubmed ID | |
Book ISBNs |
978-1-4614-6129-6, 978-1-4614-6130-2
|
Authors |
Neeta Kumari, Howard Prentice, Jang-Yen Wu |
Editors |
Abdeslem El Idrissi, William J. L'Amoreaux |
Abstract |
Taurine plays multiple roles in the CNS including acting as a -neuro-modulator, an osmoregulator, a regulator of cytoplasmic calcium levels, a trophic factor in development, and a neuroprotectant. In neurons taurine has been shown to prevent mitochondrial dysfunction and to protect against endoplasmic reticulum (ER) stress associated with neurological disorders. In cortical neurons in culture taurine protects against excitotoxicity through reversing an increase in levels of key ER signaling components including eIF-2-alpha and cleaved ATF6. The role of communication between the ER and mitochondrion is also important and examples are presented of protection by taurine against ER stress together with prevention of subsequent mitochondrial initiated apoptosis. |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
Chile | 1 | 2% |
United States | 1 | 2% |
Unknown | 50 | 96% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Researcher | 11 | 21% |
Student > Ph. D. Student | 8 | 15% |
Student > Bachelor | 7 | 13% |
Student > Master | 5 | 10% |
Professor | 3 | 6% |
Other | 8 | 15% |
Unknown | 10 | 19% |
Readers by discipline | Count | As % |
---|---|---|
Agricultural and Biological Sciences | 12 | 23% |
Pharmacology, Toxicology and Pharmaceutical Science | 5 | 10% |
Biochemistry, Genetics and Molecular Biology | 5 | 10% |
Neuroscience | 5 | 10% |
Medicine and Dentistry | 5 | 10% |
Other | 7 | 13% |
Unknown | 13 | 25% |