Title |
Patient-Centeredness in the Design of Clinical Trials
|
---|---|
Published in |
Value in Health (Elsevier Science), May 2014
|
DOI | 10.1016/j.jval.2014.02.012 |
Pubmed ID | |
Authors |
C. Daniel Mullins, Joseph Vandigo, Zhiyuan Zheng, Paul Wicks |
Abstract |
Evidence from clinical trials should contribute to informed decision making and a learning health care system. People frequently, however, find participating in clinical trials meaningless or disempowering. Moreover, people often do not incorporate trial results directly into their decision making. The lack of patient centeredness in clinical trials may be partially addressed through trial design. For example, Bayesian adaptive trials designed to adjust in a prespecified manner to changes in clinical practice could motivate people and their health care providers to view clinical trials as more applicable to real-world clinical decisions. The way in which clinical trials are designed can transform the evidence generation process to be more patient centered, providing people with an incentive to participate or continue participating in clinical trials. To achieve the transformation to patient-centeredness in clinical trial decisions, however, there is a need for transparent and reliable methods and education of trial investigators and site personnel. |
X Demographics
Geographical breakdown
Country | Count | As % |
---|---|---|
United Kingdom | 14 | 27% |
United States | 11 | 21% |
Switzerland | 2 | 4% |
Denmark | 1 | 2% |
Australia | 1 | 2% |
Norway | 1 | 2% |
Canada | 1 | 2% |
Côte d'Ivoire | 1 | 2% |
Unknown | 20 | 38% |
Demographic breakdown
Type | Count | As % |
---|---|---|
Members of the public | 35 | 67% |
Scientists | 13 | 25% |
Practitioners (doctors, other healthcare professionals) | 4 | 8% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
United States | 5 | 4% |
United Kingdom | 3 | 2% |
Spain | 2 | 1% |
Canada | 1 | <1% |
Unknown | 126 | 92% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Researcher | 26 | 19% |
Student > Master | 25 | 18% |
Student > Ph. D. Student | 14 | 10% |
Other | 12 | 9% |
Student > Bachelor | 9 | 7% |
Other | 21 | 15% |
Unknown | 30 | 22% |
Readers by discipline | Count | As % |
---|---|---|
Medicine and Dentistry | 46 | 34% |
Pharmacology, Toxicology and Pharmaceutical Science | 9 | 7% |
Agricultural and Biological Sciences | 9 | 7% |
Nursing and Health Professions | 8 | 6% |
Biochemistry, Genetics and Molecular Biology | 6 | 4% |
Other | 22 | 16% |
Unknown | 37 | 27% |