Title |
Aberrant Mucin Assembly in Mice Causes Endoplasmic Reticulum Stress and Spontaneous Inflammation Resembling Ulcerative Colitis
|
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Published in |
PLOS Medicine, March 2008
|
DOI | 10.1371/journal.pmed.0050054 |
Pubmed ID | |
Authors |
Chad K Heazlewood, Matthew C Cook, Rajaraman Eri, Gareth R Price, Sharyn B Tauro, Douglas Taupin, David J Thornton, Chin Wen Png, Tanya L Crockford, Richard J Cornall, Rachel Adams, Masato Kato, Keats A Nelms, Nancy A Hong, Timothy H. J Florin, Christopher C Goodnow, Michael A McGuckin |
Abstract |
MUC2 mucin produced by intestinal goblet cells is the major component of the intestinal mucus barrier. The inflammatory bowel disease ulcerative colitis is characterized by depleted goblet cells and a reduced mucus layer, but the aetiology remains obscure. In this study we used random mutagenesis to produce two murine models of inflammatory bowel disease, characterised the basis and nature of the inflammation in these mice, and compared the pathology with human ulcerative colitis. |
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Geographical breakdown
Country | Count | As % |
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United States | 5 | 1% |
United Kingdom | 2 | <1% |
Germany | 2 | <1% |
Australia | 1 | <1% |
Ireland | 1 | <1% |
Belgium | 1 | <1% |
Canada | 1 | <1% |
Japan | 1 | <1% |
Denmark | 1 | <1% |
Other | 0 | 0% |
Unknown | 352 | 96% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Student > Ph. D. Student | 85 | 23% |
Researcher | 69 | 19% |
Student > Master | 50 | 14% |
Student > Bachelor | 35 | 10% |
Student > Postgraduate | 15 | 4% |
Other | 57 | 16% |
Unknown | 56 | 15% |
Readers by discipline | Count | As % |
---|---|---|
Agricultural and Biological Sciences | 111 | 30% |
Medicine and Dentistry | 55 | 15% |
Immunology and Microbiology | 50 | 14% |
Biochemistry, Genetics and Molecular Biology | 48 | 13% |
Pharmacology, Toxicology and Pharmaceutical Science | 9 | 2% |
Other | 27 | 7% |
Unknown | 67 | 18% |