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Aberrant Mucin Assembly in Mice Causes Endoplasmic Reticulum Stress and Spontaneous Inflammation Resembling Ulcerative Colitis

Overview of attention for article published in PLOS Medicine, March 2008
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Citations

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Readers on

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367 Mendeley
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Title
Aberrant Mucin Assembly in Mice Causes Endoplasmic Reticulum Stress and Spontaneous Inflammation Resembling Ulcerative Colitis
Published in
PLOS Medicine, March 2008
DOI 10.1371/journal.pmed.0050054
Pubmed ID
Authors

Chad K Heazlewood, Matthew C Cook, Rajaraman Eri, Gareth R Price, Sharyn B Tauro, Douglas Taupin, David J Thornton, Chin Wen Png, Tanya L Crockford, Richard J Cornall, Rachel Adams, Masato Kato, Keats A Nelms, Nancy A Hong, Timothy H. J Florin, Christopher C Goodnow, Michael A McGuckin

Abstract

MUC2 mucin produced by intestinal goblet cells is the major component of the intestinal mucus barrier. The inflammatory bowel disease ulcerative colitis is characterized by depleted goblet cells and a reduced mucus layer, but the aetiology remains obscure. In this study we used random mutagenesis to produce two murine models of inflammatory bowel disease, characterised the basis and nature of the inflammation in these mice, and compared the pathology with human ulcerative colitis.

Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 367 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
United States 5 1%
United Kingdom 2 <1%
Germany 2 <1%
Australia 1 <1%
Ireland 1 <1%
Belgium 1 <1%
Canada 1 <1%
Japan 1 <1%
Denmark 1 <1%
Other 0 0%
Unknown 352 96%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 85 23%
Researcher 69 19%
Student > Master 50 14%
Student > Bachelor 35 10%
Student > Postgraduate 15 4%
Other 57 16%
Unknown 56 15%
Readers by discipline Count As %
Agricultural and Biological Sciences 111 30%
Medicine and Dentistry 55 15%
Immunology and Microbiology 50 14%
Biochemistry, Genetics and Molecular Biology 48 13%
Pharmacology, Toxicology and Pharmaceutical Science 9 2%
Other 27 7%
Unknown 67 18%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 05 February 2009.
All research outputs
#17,286,379
of 25,374,917 outputs
Outputs from PLOS Medicine
#4,928
of 5,161 outputs
Outputs of similar age
#82,340
of 95,786 outputs
Outputs of similar age from PLOS Medicine
#56
of 60 outputs
Altmetric has tracked 25,374,917 research outputs across all sources so far. This one is in the 21st percentile – i.e., 21% of other outputs scored the same or lower than it.
So far Altmetric has tracked 5,161 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 77.7. This one is in the 2nd percentile – i.e., 2% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 95,786 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 7th percentile – i.e., 7% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 60 others from the same source and published within six weeks on either side of this one. This one is in the 6th percentile – i.e., 6% of its contemporaries scored the same or lower than it.