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Mendeley readers
Attention Score in Context
| Title |
Clinical correlates and genetic linkage of social and communication difficulties in families with obsessive–compulsive disorder: Results from the OCD Collaborative Genetics Study
|
|---|---|
| Published in |
American Journal of Medical Genetics. Part B, Neuropsychiatric Genetics: The Official Publication of the International Society of Psychiatric Genetics, May 2014
|
| DOI | 10.1002/ajmg.b.32235 |
| Pubmed ID | |
| Authors |
Jack Samuels, Yin Yao Shugart, Ying Wang, Marco A. Grados, O. Joseph Bienvenu, Anthony Pinto, Scott L. Rauch, Benjamin D. Greenberg, James A. Knowles, Abby J. Fyer, John Piacentini, David L. Pauls, Bernadette Cullen, Steven A. Rasmussen, S. Evelyn Stewart, Dan A. Geller, Brion S. Maher, Fernando S. Goes, Dennis L. Murphy, James T. McCracken, Mark A. Riddle, Gerald Nestadt |
| Abstract |
Some individuals with obsessive-compulsive disorder (OCD) have autistic-like traits, including deficits in social and communication behaviors (pragmatics). The objective of this study was to determine if pragmatic impairment aggregates in OCD families and discriminates a clinically and genetically distinct subtype of OCD. We conducted clinical examinations on, and collected DNA samples from, 706 individuals with OCD in 221 multiply affected OCD families. Using the Pragmatic Rating Scale (PRS), we compared the prevalence of pragmatic impairment in OCD-affected relatives of probands with and without pragmatic impairment. We also compared clinical features of OCD-affected individuals in families having at least one, versus no, individual with pragmatic impairment, and assessed for linkage to OCD in the two groups of families. The odds of pragmatic impairment were substantially greater in OCD-affected relatives of probands with pragmatic impairment. Individuals in high-PRS families had greater odds of separation anxiety disorder and social phobia, and a greater number of schizotypal personality traits. In high-PRS families, there was suggestive linkage to OCD on chromosome 12 at marker D12S1064 and on chromosome X at marker DXS7132 whereas, in low-PRS families, there was suggestive linkage to chromosome 3 at marker D3S2398. Pragmatic impairment aggregates in OCD families. Separation anxiety disorder, social phobia, and schizotypal personality traits are part of a clinical spectrum associated with pragmatic impairment in these families. Specific regions of chromosomes 12 and X are linked to OCD in high-PRS families. Thus, pragmatic impairment may distinguish a clinically and genetically homogeneous subtype of OCD. © 2014 Wiley Periodicals, Inc. |
Mendeley readers
The data shown below were compiled from readership statistics for 88 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 1 | 1% |
| Denmark | 1 | 1% |
| Unknown | 86 | 98% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 18 | 20% |
| Student > Master | 15 | 17% |
| Researcher | 10 | 11% |
| Student > Doctoral Student | 10 | 11% |
| Professor | 5 | 6% |
| Other | 12 | 14% |
| Unknown | 18 | 20% |
| Readers by discipline | Count | As % |
|---|---|---|
| Psychology | 31 | 35% |
| Medicine and Dentistry | 20 | 23% |
| Agricultural and Biological Sciences | 4 | 5% |
| Biochemistry, Genetics and Molecular Biology | 3 | 3% |
| Neuroscience | 3 | 3% |
| Other | 5 | 6% |
| Unknown | 22 | 25% |
Attention Score in Context
This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 07 May 2014.
All research outputs
#17,489,487
of 25,654,806 outputs
Outputs from American Journal of Medical Genetics. Part B, Neuropsychiatric Genetics: The Official Publication of the International Society of Psychiatric Genetics
#820
of 1,161 outputs
Outputs of similar age
#147,054
of 242,753 outputs
Outputs of similar age from American Journal of Medical Genetics. Part B, Neuropsychiatric Genetics: The Official Publication of the International Society of Psychiatric Genetics
#6
of 14 outputs
Altmetric has tracked 25,654,806 research outputs across all sources so far. This one is in the 21st percentile – i.e., 21% of other outputs scored the same or lower than it.
So far Altmetric has tracked 1,161 research outputs from this source. They typically receive a little more attention than average, with a mean Attention Score of 5.6. This one is in the 21st percentile – i.e., 21% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 242,753 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 30th percentile – i.e., 30% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 14 others from the same source and published within six weeks on either side of this one. This one has gotten more attention than average, scoring higher than 50% of its contemporaries.