| Title |
Insulin Resistance, Diabetes, and Cardiovascular Risk
|
|---|---|
| Published in |
Current Atherosclerosis Reports, April 2014
|
| DOI | 10.1007/s11883-014-0419-z |
| Pubmed ID | |
| Authors |
Francesco Paneni, Sarah Costantino, Francesco Cosentino |
| Abstract |
Obesity and type 2 diabetes mellitus (T2DM) are major drivers of cardiovascular disease (CVD). The link between environmental factors, obesity, and dysglycemia indicates that progression to diabetes with time occurs along a "continuum", not necessarily linear, which involves different cellular mechanisms including alterations of insulin signaling, changes in glucose transport, pancreatic beta cell dysfunction, as well as the deregulation of key genes involved in oxidative stress and inflammation. The present review critically addresses key pathophysiological aspects including (i) hyperglycemia and insulin resistance as predictors of CV outcome, (ii) molecular mechanisms underpinning the progression of diabetic vascular complications despite intensive glycemic control, and (iii) stratification of CV risk, with particular emphasis on emerging biomarkers. Taken together, these important aspects may contribute to the development of promising diagnostic approaches as well as mechanism-based therapeutic strategies to reduce CVD burden in obese and diabetic subjects. |
X Demographics
The data shown below were collected from the profiles of 2 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| India | 1 | 50% |
| Spain | 1 | 50% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 2 | 100% |
Mendeley readers
The data shown below were compiled from readership statistics for 107 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Mexico | 1 | <1% |
| Spain | 1 | <1% |
| Brazil | 1 | <1% |
| Unknown | 104 | 97% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Master | 16 | 15% |
| Student > Bachelor | 16 | 15% |
| Researcher | 14 | 13% |
| Student > Doctoral Student | 11 | 10% |
| Student > Postgraduate | 9 | 8% |
| Other | 23 | 21% |
| Unknown | 18 | 17% |
| Readers by discipline | Count | As % |
|---|---|---|
| Medicine and Dentistry | 35 | 33% |
| Agricultural and Biological Sciences | 14 | 13% |
| Biochemistry, Genetics and Molecular Biology | 11 | 10% |
| Nursing and Health Professions | 9 | 8% |
| Computer Science | 3 | 3% |
| Other | 11 | 10% |
| Unknown | 24 | 22% |
Attention Score in Context
This research output has an Altmetric Attention Score of 2. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 06 June 2014.
All research outputs
#14,195,754
of 22,755,127 outputs
Outputs from Current Atherosclerosis Reports
#531
of 762 outputs
Outputs of similar age
#120,466
of 227,058 outputs
Outputs of similar age from Current Atherosclerosis Reports
#7
of 11 outputs
Altmetric has tracked 22,755,127 research outputs across all sources so far. This one is in the 35th percentile – i.e., 35% of other outputs scored the same or lower than it.
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We're also able to compare this research output to 11 others from the same source and published within six weeks on either side of this one. This one is in the 36th percentile – i.e., 36% of its contemporaries scored the same or lower than it.