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Treatment failure in leishmaniasis: drug-resistance or another (epi-) phenotype?

Overview of attention for article published in Expert Review of Anti-Infective Therapy, May 2014
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2 X users

Citations

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68 Dimensions

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86 Mendeley
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Title
Treatment failure in leishmaniasis: drug-resistance or another (epi-) phenotype?
Published in
Expert Review of Anti-Infective Therapy, May 2014
DOI 10.1586/14787210.2014.916614
Pubmed ID
Authors

Manu Vanaerschot, Franck Dumetz, Syamal Roy, Alicia Ponte-Sucre, Jorge Arevalo, Jean-Claude Dujardin

Abstract

Two major leishmaniasis treatments have shown a significant decrease in effectiveness in the last few decades, mostly in the Indian subcontinent but also in other endemic areas. Drug resistance of Leishmania correlated only partially to treatment failure (TF) of pentavalent antimonials, and has so far proved not to be important for the increased miltefosine relapse rates observed in the Indian subcontinent. While other patient- or drug-related factors could also have played a role, recent studies identified several parasite features such as infectivity and host manipulation skills that might contribute to TF. This perspective aims to discuss how different parasitic features other than drug resistance can contribute to TF of leishmaniasis and how this may vary between different epidemiological contexts.

X Demographics

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The data shown below were collected from the profiles of 2 X users who shared this research output. Click here to find out more about how the information was compiled.
Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 86 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 86 100%

Demographic breakdown

Readers by professional status Count As %
Student > Master 18 21%
Student > Ph. D. Student 13 15%
Researcher 11 13%
Student > Bachelor 7 8%
Student > Postgraduate 5 6%
Other 12 14%
Unknown 20 23%
Readers by discipline Count As %
Agricultural and Biological Sciences 16 19%
Biochemistry, Genetics and Molecular Biology 16 19%
Medicine and Dentistry 10 12%
Immunology and Microbiology 5 6%
Pharmacology, Toxicology and Pharmaceutical Science 4 5%
Other 11 13%
Unknown 24 28%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 09 May 2014.
All research outputs
#17,289,387
of 25,377,790 outputs
Outputs from Expert Review of Anti-Infective Therapy
#953
of 1,340 outputs
Outputs of similar age
#145,902
of 241,911 outputs
Outputs of similar age from Expert Review of Anti-Infective Therapy
#17
of 27 outputs
Altmetric has tracked 25,377,790 research outputs across all sources so far. This one is in the 21st percentile – i.e., 21% of other outputs scored the same or lower than it.
So far Altmetric has tracked 1,340 research outputs from this source. They typically receive more attention than average, with a mean Attention Score of 7.9. This one is in the 21st percentile – i.e., 21% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 241,911 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 30th percentile – i.e., 30% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 27 others from the same source and published within six weeks on either side of this one. This one is in the 37th percentile – i.e., 37% of its contemporaries scored the same or lower than it.