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Attention Score in Context
| Title |
Structure–activity relationship of lipid core peptide-based Group A Streptococcus vaccine candidates
|
|---|---|
| Published in |
Bioorganic & Medicinal Chemistry, April 2016
|
| DOI | 10.1016/j.bmc.2016.03.063 |
| Pubmed ID | |
| Authors |
Amy Chan, Waleed M. Hussein, Khairunnisa Abdul Ghaffar, Nirmal Marasini, Ahmed Mostafa, Sharareh Eskandari, Michael R. Batzloff, Michael F. Good, Mariusz Skwarczynski, Istvan Toth |
| Abstract |
Infection with Group A Streptococcus (GAS) can result in a range of different illnesses, some of which are fatal. Currently, our efforts to develop a vaccine against GAS focuses on the lipid core peptide (LCP) system, a subunit vaccine containing a lipoamino acid (LAA) moiety which allows the stimulation of systemic antibody activity. In the present study, a peptide (J14) representing the B-cell epitope from the GAS M protein was incorporated alongside a universal T-helper epitope (P25) in four LCP constructs of different spatial orientation or LAA lengths. Through structure-activity studies, it was discovered that while the alteration of the LCP orientation had a weaker effect on immunostimulation, increasing the LAA side chain length within the construct increased antibody responses in murine models. Furthermore, the mice immunised with the lead LCP construct were also able to maintain antibody activity throughout the course of five months. These findings highlight the importance of LAA moieties in the development of intranasal peptide vaccines and confirmed that its side chain length has an effect on the immunogenicity of the structure. |
X Demographics
The data shown below were collected from the profile of 1 X user who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 1 | 100% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 1 | 100% |
Mendeley readers
The data shown below were compiled from readership statistics for 11 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 11 | 100% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 3 | 27% |
| Student > Master | 2 | 18% |
| Researcher | 2 | 18% |
| Student > Bachelor | 1 | 9% |
| Other | 1 | 9% |
| Other | 1 | 9% |
| Unknown | 1 | 9% |
| Readers by discipline | Count | As % |
|---|---|---|
| Chemistry | 3 | 27% |
| Agricultural and Biological Sciences | 2 | 18% |
| Immunology and Microbiology | 2 | 18% |
| Biochemistry, Genetics and Molecular Biology | 1 | 9% |
| Arts and Humanities | 1 | 9% |
| Other | 2 | 18% |
Attention Score in Context
This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 03 August 2017.
All research outputs
#22,758,309
of 25,373,627 outputs
Outputs from Bioorganic & Medicinal Chemistry
#6,975
of 7,493 outputs
Outputs of similar age
#272,117
of 314,992 outputs
Outputs of similar age from Bioorganic & Medicinal Chemistry
#72
of 89 outputs
Altmetric has tracked 25,373,627 research outputs across all sources so far. This one is in the 1st percentile – i.e., 1% of other outputs scored the same or lower than it.
So far Altmetric has tracked 7,493 research outputs from this source. They receive a mean Attention Score of 4.8. This one is in the 1st percentile – i.e., 1% of its peers scored the same or lower than it.
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We're also able to compare this research output to 89 others from the same source and published within six weeks on either side of this one. This one is in the 1st percentile – i.e., 1% of its contemporaries scored the same or lower than it.