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X Demographics
Mendeley readers
Attention Score in Context
| Title |
Repression of Stress-Induced LINE-1 Expression Protects Cancer Cell Subpopulations from Lethal Drug Exposure
|
|---|---|
| Published in |
Cancer Cell, August 2017
|
| DOI | 10.1016/j.ccell.2017.07.002 |
| Pubmed ID | |
| Authors |
Gulfem Dilek Guler, Charles Albert Tindell, Robert Pitti, Catherine Wilson, Katrina Nichols, Tommy KaiWai Cheung, Hyo-Jin Kim, Matthew Wongchenko, Yibing Yan, Benjamin Haley, Trinna Cuellar, Joshua Webster, Navneet Alag, Ganapati Hegde, Erica Jackson, Tracy Leah Nance, Paul Garrett Giresi, Kuan-Bei Chen, Jinfeng Liu, Suchit Jhunjhunwala, Jeff Settleman, Jean-Philippe Stephan, David Arnott, Marie Classon |
| Abstract |
Maintenance of phenotypic heterogeneity within cell populations is an evolutionarily conserved mechanism that underlies population survival upon stressful exposures. We show that the genomes of a cancer cell subpopulation that survives treatment with otherwise lethal drugs, the drug-tolerant persisters (DTPs), exhibit a repressed chromatin state characterized by increased methylation of histone H3 lysines 9 and 27 (H3K9 and H3K27). We also show that survival of DTPs is, in part, maintained by regulators of H3K9me3-mediated heterochromatin formation and that the observed increase in H3K9me3 in DTPs is most prominent over long interspersed repeat element 1 (LINE-1). Disruption of the repressive chromatin over LINE-1 elements in DTPs results in DTP ablation, which is partially rescued by reducing LINE-1 expression or function. |
X Demographics
The data shown below were collected from the profiles of 34 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 11 | 32% |
| United Kingdom | 2 | 6% |
| Venezuela, Bolivarian Republic of | 1 | 3% |
| India | 1 | 3% |
| France | 1 | 3% |
| Germany | 1 | 3% |
| Bangladesh | 1 | 3% |
| Canada | 1 | 3% |
| Netherlands | 1 | 3% |
| Other | 3 | 9% |
| Unknown | 11 | 32% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 17 | 50% |
| Scientists | 15 | 44% |
| Science communicators (journalists, bloggers, editors) | 2 | 6% |
Mendeley readers
The data shown below were compiled from readership statistics for 273 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 273 | 100% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 68 | 25% |
| Researcher | 53 | 19% |
| Student > Master | 28 | 10% |
| Student > Bachelor | 18 | 7% |
| Student > Doctoral Student | 15 | 5% |
| Other | 39 | 14% |
| Unknown | 52 | 19% |
| Readers by discipline | Count | As % |
|---|---|---|
| Biochemistry, Genetics and Molecular Biology | 110 | 40% |
| Agricultural and Biological Sciences | 53 | 19% |
| Medicine and Dentistry | 21 | 8% |
| Engineering | 6 | 2% |
| Immunology and Microbiology | 5 | 2% |
| Other | 22 | 8% |
| Unknown | 56 | 21% |
Attention Score in Context
This research output has an Altmetric Attention Score of 21. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 09 December 2021.
All research outputs
#1,822,057
of 25,497,142 outputs
Outputs from Cancer Cell
#1,218
of 3,162 outputs
Outputs of similar age
#34,762
of 327,503 outputs
Outputs of similar age from Cancer Cell
#18
of 36 outputs
Altmetric has tracked 25,497,142 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 92nd percentile: it's in the top 10% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 3,162 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 37.4. This one has gotten more attention than average, scoring higher than 61% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 327,503 tracked outputs that were published within six weeks on either side of this one in any source. This one has done well, scoring higher than 89% of its contemporaries.
We're also able to compare this research output to 36 others from the same source and published within six weeks on either side of this one. This one has gotten more attention than average, scoring higher than 52% of its contemporaries.