| Title |
Metformin therapy for the reproductive and metabolic consequences of polycystic ovary syndrome
|
|---|---|
| Published in |
Diabetologia, August 2017
|
| DOI | 10.1007/s00125-017-4306-3 |
| Pubmed ID | |
| Authors |
Susan Sam, David A. Ehrmann |
| Abstract |
Polycystic ovary syndrome (PCOS), the most common hormonal disorder among women of reproductive age, has various metabolic and reproductive consequences. Metformin was originally shown to lower testosterone levels in women with PCOS in the 1990s, an effect presumably related to its insulin sensitising actions. However, the precise mechanisms of metformin action in PCOS remain unclear and there is considerable heterogeneity in the clinical response to this therapy in women with PCOS. Recent evidence indicates that genetic factors may play a significant role in predicting response to metformin therapy in PCOS and future studies are needed to further identify women who are most likely to benefit from this therapy. At present, there is no clear evidence to support broad metformin use in PCOS. Well-designed prospective trials are needed to establish clear benefit for metformin use in the treatment of the reproductive and metabolic consequences associated with PCOS. |
X Demographics
The data shown below were collected from the profiles of 46 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Spain | 10 | 22% |
| United Kingdom | 8 | 17% |
| Mexico | 2 | 4% |
| Italy | 1 | 2% |
| India | 1 | 2% |
| Saudi Arabia | 1 | 2% |
| Peru | 1 | 2% |
| Paraguay | 1 | 2% |
| Unknown | 21 | 46% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 33 | 72% |
| Practitioners (doctors, other healthcare professionals) | 8 | 17% |
| Scientists | 5 | 11% |
Mendeley readers
The data shown below were compiled from readership statistics for 106 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 106 | 100% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Bachelor | 15 | 14% |
| Student > Master | 11 | 10% |
| Student > Ph. D. Student | 10 | 9% |
| Other | 9 | 8% |
| Researcher | 8 | 8% |
| Other | 17 | 16% |
| Unknown | 36 | 34% |
| Readers by discipline | Count | As % |
|---|---|---|
| Medicine and Dentistry | 25 | 24% |
| Biochemistry, Genetics and Molecular Biology | 14 | 13% |
| Nursing and Health Professions | 7 | 7% |
| Agricultural and Biological Sciences | 7 | 7% |
| Pharmacology, Toxicology and Pharmaceutical Science | 6 | 6% |
| Other | 7 | 7% |
| Unknown | 40 | 38% |
Attention Score in Context
This research output has an Altmetric Attention Score of 401. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 07 January 2023.
All research outputs
#76,148
of 25,732,188 outputs
Outputs from Diabetologia
#63
of 5,376 outputs
Outputs of similar age
#1,698
of 328,189 outputs
Outputs of similar age from Diabetologia
#2
of 95 outputs
Altmetric has tracked 25,732,188 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 99th percentile: it's in the top 5% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 5,376 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 24.8. This one has done particularly well, scoring higher than 98% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 328,189 tracked outputs that were published within six weeks on either side of this one in any source. This one has done particularly well, scoring higher than 99% of its contemporaries.
We're also able to compare this research output to 95 others from the same source and published within six weeks on either side of this one. This one has done particularly well, scoring higher than 97% of its contemporaries.