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Does the microbiome play a causal role in spondyloarthritis?

Overview of attention for article published in Clinical Rheumatology, May 2014
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1 X user

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26 Dimensions

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Title
Does the microbiome play a causal role in spondyloarthritis?
Published in
Clinical Rheumatology, May 2014
DOI 10.1007/s10067-014-2664-5
Pubmed ID
Authors

James T. Rosenbaum, Phoebe Lin, Mark Asquith, Mary-Ellen Costello, Tony J. Kenna, Matthew A. Brown

Abstract

The purpose of this study is to review the potential causal role of the microbiome in the pathogenesis of spondyloarthritis. The method used for the study is literature review. The microbiome plays a major role in educating the immune response. The microbiome is strongly implicated in inflammatory bowel disease which has clinical and genetic overlap with spondyloarthritis. The microbiome also plays a causal role in bowel and joint disease in HLA B27/human beta 2 microglobulin transgenic rats. The mechanism(s) by which HLA B27 could influence the microbiome is unknown but theories include an immune response gene selectivity, an effect on dendritic cell function, or a mucosal immunodeficiency. Bacteria are strongly implicated in the pathogenesis of spondyloarthritis. Studies to understand how HLA B27 affects bacterial ecosystems should be encouraged.

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X Demographics

The data shown below were collected from the profile of 1 X user who shared this research output. Click here to find out more about how the information was compiled.
Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 59 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
United Kingdom 1 2%
Unknown 58 98%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 14 24%
Other 8 14%
Student > Master 8 14%
Researcher 7 12%
Professor 4 7%
Other 12 20%
Unknown 6 10%
Readers by discipline Count As %
Medicine and Dentistry 26 44%
Agricultural and Biological Sciences 11 19%
Biochemistry, Genetics and Molecular Biology 4 7%
Immunology and Microbiology 2 3%
Chemistry 2 3%
Other 4 7%
Unknown 10 17%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 10 May 2014.
All research outputs
#15,300,431
of 22,755,127 outputs
Outputs from Clinical Rheumatology
#1,977
of 2,988 outputs
Outputs of similar age
#133,761
of 227,074 outputs
Outputs of similar age from Clinical Rheumatology
#27
of 67 outputs
Altmetric has tracked 22,755,127 research outputs across all sources so far. This one is in the 22nd percentile – i.e., 22% of other outputs scored the same or lower than it.
So far Altmetric has tracked 2,988 research outputs from this source. They typically receive a little more attention than average, with a mean Attention Score of 6.9. This one is in the 26th percentile – i.e., 26% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 227,074 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 31st percentile – i.e., 31% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 67 others from the same source and published within six weeks on either side of this one. This one is in the 31st percentile – i.e., 31% of its contemporaries scored the same or lower than it.