| Title |
Caffeine intake during pregnancy, late miscarriage and stillbirth
|
|---|---|
| Published in |
European Journal of Epidemiology, March 2010
|
| DOI | 10.1007/s10654-010-9443-7 |
| Pubmed ID | |
| Authors |
Darren C. Greenwood, Nisreen Alwan, Sinead Boylan, Janet E. Cade, Jim Charvill, Karen C. Chipps, Marcus S. Cooke, Vivien A. Dolby, Alastair W. M. Hay, Shabira Kassam, Sara F. L. Kirk, Justin C. Konje, Neelam Potdar, Susan Shires, Nigel Simpson, Nicholas Taub, James D. Thomas, James Walker, Kay L. M. White, Christopher P. Wild |
| Abstract |
Caffeine is a commonly consumed drug during pregnancy with the potential to affect the developing fetus. Findings from previous studies have shown inconsistent results. We recruited a cohort of 2,643 pregnant women, aged 18-45 years, attending two UK maternity units between 8 and 12 weeks gestation from September 2003 to June 2006. We used a validated tool to assess caffeine intake at different stages of pregnancy and related this to late miscarriage and stillbirth, adjusting for confounders, including salivary cotinine as a biomarker of smoking status. There was a strong association between caffeine intake in the first trimester and subsequent late miscarriage and stillbirth, adjusting for confounders. Women whose pregnancies resulted in late miscarriage or stillbirth had higher caffeine intakes (geometric mean = 145 mg/day; 95% CI: 85-249) than those with live births (103 mg/day; 95% CI: 98-108). Compared to those consuming < 100 mg/day, odds ratios increased to 2.2 (95% CI: 0.7-7.1) for 100-199 mg/day, 1.7 (0.4-7.1) for 200-299 mg/day, and 5.1 (1.6-16.4) for 300+ mg/day (P (trend) = 0.004). Greater caffeine intake is associated with increases in late miscarriage and stillbirth. Despite remaining uncertainty in the strength of association, our study strengthens the observational evidence base on which current guidance is founded. |
Mendeley readers
The data shown below were compiled from readership statistics for 106 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Australia | 2 | 2% |
| United Kingdom | 1 | <1% |
| France | 1 | <1% |
| Spain | 1 | <1% |
| Unknown | 101 | 95% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Bachelor | 29 | 27% |
| Student > Master | 17 | 16% |
| Researcher | 13 | 12% |
| Student > Ph. D. Student | 10 | 9% |
| Professor > Associate Professor | 4 | 4% |
| Other | 13 | 12% |
| Unknown | 20 | 19% |
| Readers by discipline | Count | As % |
|---|---|---|
| Medicine and Dentistry | 40 | 38% |
| Agricultural and Biological Sciences | 9 | 8% |
| Nursing and Health Professions | 8 | 8% |
| Biochemistry, Genetics and Molecular Biology | 8 | 8% |
| Arts and Humanities | 5 | 5% |
| Other | 12 | 11% |
| Unknown | 24 | 23% |
Attention Score in Context
This research output has an Altmetric Attention Score of 11. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 01 January 2019.
All research outputs
#2,903,174
of 23,957,285 outputs
Outputs from European Journal of Epidemiology
#384
of 1,735 outputs
Outputs of similar age
#11,274
of 97,295 outputs
Outputs of similar age from European Journal of Epidemiology
#3
of 16 outputs
Altmetric has tracked 23,957,285 research outputs across all sources so far. Compared to these this one has done well and is in the 87th percentile: it's in the top 25% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 1,735 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 39.3. This one has done well, scoring higher than 77% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 97,295 tracked outputs that were published within six weeks on either side of this one in any source. This one has done well, scoring higher than 88% of its contemporaries.
We're also able to compare this research output to 16 others from the same source and published within six weeks on either side of this one. This one has done well, scoring higher than 87% of its contemporaries.