Title |
Mollemycin A: An Antimalarial and Antibacterial Glyco-hexadepsipeptide-polyketide from an Australian Marine-Derived Streptomyces sp. (CMB-M0244)
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Published in |
Organic Letters, March 2014
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DOI | 10.1021/ol5003913 |
Pubmed ID | |
Authors |
Ritesh Raju, Zeinab G. Khalil, Andrew M. Piggott, Antje Blumenthal, Donald L. Gardiner, Tina S. Skinner-Adams, Robert J. Capon |
Abstract |
A marine-derived Streptomyces sp. (CMB-M0244) isolated from a sediment collected off South Molle Island, Queensland, produced mollemycin A (1) as a new first in class glyco-hexadepsipeptide-polyketide. The structure of 1 was assigned by detailed spectroscopic analysis, supported by chemical derivatization and degradation, and C3 Marfey's analysis. Mollemycin A (1) exhibits exceptionally potent and selective growth inhibitory activity against Gram-positive and Gram-negative bacteria (IC50 10-50 nM) and drug-sensitive (3D7; IC50 7 nM) and multidrug-resistant (Dd2; IC50 9 nM) clones of the malaria parasite Plasmodium falciparum. |
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