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X Demographics
Mendeley readers
Attention Score in Context
| Title |
The noncoding RNA IPW regulates the imprinted DLK1-DIO3 locus in an induced pluripotent stem cell model of Prader-Willi syndrome
|
|---|---|
| Published in |
Nature Genetics, May 2014
|
| DOI | 10.1038/ng.2968 |
| Pubmed ID | |
| Authors |
Yonatan Stelzer, Ido Sagi, Ofra Yanuka, Rachel Eiges, Nissim Benvenisty |
| Abstract |
Parental imprinting is a form of epigenetic regulation that results in parent-of-origin differential gene expression. To study Prader-Willi syndrome (PWS), a developmental imprinting disorder, we generated case-derived induced pluripotent stem cells (iPSCs) harboring distinct aberrations in the affected region on chromosome 15. In studying PWS-iPSCs and human parthenogenetic iPSCs, we unexpectedly found substantial upregulation of virtually all maternally expressed genes (MEGs) in the imprinted DLK1-DIO3 locus on chromosome 14. Subsequently, we determined that IPW, a long noncoding RNA in the critical region of the PWS locus, is a regulator of the DLK1-DIO3 region, as its overexpression in PWS and parthenogenetic iPSCs resulted in downregulation of MEGs in this locus. We further show that gene expression changes in the DLK1-DIO3 region coincide with chromatin modifications rather than DNA methylation levels. Our results suggest that a subset of PWS phenotypes may arise from dysregulation of an imprinted locus distinct from the PWS region. |
X Demographics
The data shown below were collected from the profiles of 9 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 3 | 33% |
| United Kingdom | 3 | 33% |
| Unknown | 3 | 33% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 5 | 56% |
| Scientists | 3 | 33% |
| Science communicators (journalists, bloggers, editors) | 1 | 11% |
Mendeley readers
The data shown below were compiled from readership statistics for 191 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 5 | 3% |
| Japan | 2 | 1% |
| United Kingdom | 1 | <1% |
| China | 1 | <1% |
| Canada | 1 | <1% |
| Mexico | 1 | <1% |
| Spain | 1 | <1% |
| Unknown | 179 | 94% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Researcher | 52 | 27% |
| Student > Ph. D. Student | 50 | 26% |
| Student > Master | 13 | 7% |
| Student > Bachelor | 12 | 6% |
| Student > Doctoral Student | 11 | 6% |
| Other | 32 | 17% |
| Unknown | 21 | 11% |
| Readers by discipline | Count | As % |
|---|---|---|
| Agricultural and Biological Sciences | 79 | 41% |
| Biochemistry, Genetics and Molecular Biology | 51 | 27% |
| Medicine and Dentistry | 21 | 11% |
| Neuroscience | 3 | 2% |
| Computer Science | 2 | 1% |
| Other | 8 | 4% |
| Unknown | 27 | 14% |
Attention Score in Context
This research output has an Altmetric Attention Score of 54. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 24 October 2023.
All research outputs
#751,233
of 24,792,414 outputs
Outputs from Nature Genetics
#1,412
of 7,475 outputs
Outputs of similar age
#7,108
of 232,589 outputs
Outputs of similar age from Nature Genetics
#27
of 71 outputs
Altmetric has tracked 24,792,414 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 96th percentile: it's in the top 5% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 7,475 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 42.9. This one has done well, scoring higher than 81% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 232,589 tracked outputs that were published within six weeks on either side of this one in any source. This one has done particularly well, scoring higher than 96% of its contemporaries.
We're also able to compare this research output to 71 others from the same source and published within six weeks on either side of this one. This one has gotten more attention than average, scoring higher than 63% of its contemporaries.