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Mendeley readers
Attention Score in Context
| Title |
Hierarchical Rules for Argonaute Loading in Drosophila
|
|---|---|
| Published in |
Molecular Cell, November 2009
|
| DOI | 10.1016/j.molcel.2009.09.028 |
| Pubmed ID | |
| Authors |
Benjamin Czech, Rui Zhou, Yaniv Erlich, Julius Brennecke, Richard Binari, Christians Villalta, Assaf Gordon, Norbert Perrimon, Gregory J. Hannon |
| Abstract |
Drosophila Argonaute-1 and Argonaute-2 differ in function and small RNA content. AGO2 binds to siRNAs, whereas AGO1 is almost exclusively occupied by microRNAs. MicroRNA duplexes are intrinsically asymmetric, with one strand, the miR strand, preferentially entering AGO1 to recognize and regulate the expression of target mRNAs. The other strand, miR*, has been viewed as a byproduct of microRNA biogenesis. Here, we show that miR*s are often loaded as functional species into AGO2. This indicates that each microRNA precursor can potentially produce two mature small RNA strands that are differentially sorted within the RNAi pathway. miR* biogenesis depends upon the canonical microRNA pathway, but loading into AGO2 is mediated by factors traditionally dedicated to siRNAs. By inferring and validating hierarchical rules that predict differential AGO loading, we find that intrinsic determinants, including structural and thermodynamic properties of the processed duplex, regulate the fate of each RNA strand within the RNAi pathway. |
Mendeley readers
The data shown below were compiled from readership statistics for 318 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 9 | 3% |
| Portugal | 1 | <1% |
| Turkey | 1 | <1% |
| France | 1 | <1% |
| Germany | 1 | <1% |
| Brazil | 1 | <1% |
| United Kingdom | 1 | <1% |
| China | 1 | <1% |
| Korea, Republic of | 1 | <1% |
| Other | 4 | 1% |
| Unknown | 297 | 93% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 95 | 30% |
| Researcher | 64 | 20% |
| Student > Master | 35 | 11% |
| Professor > Associate Professor | 21 | 7% |
| Student > Doctoral Student | 17 | 5% |
| Other | 44 | 14% |
| Unknown | 42 | 13% |
| Readers by discipline | Count | As % |
|---|---|---|
| Agricultural and Biological Sciences | 167 | 53% |
| Biochemistry, Genetics and Molecular Biology | 74 | 23% |
| Medicine and Dentistry | 7 | 2% |
| Neuroscience | 5 | 2% |
| Chemistry | 5 | 2% |
| Other | 16 | 5% |
| Unknown | 44 | 14% |
Attention Score in Context
This research output has an Altmetric Attention Score of 4. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 27 December 2022.
All research outputs
#7,356,550
of 25,377,790 outputs
Outputs from Molecular Cell
#4,812
of 7,617 outputs
Outputs of similar age
#33,646
of 108,548 outputs
Outputs of similar age from Molecular Cell
#32
of 72 outputs
Altmetric has tracked 25,377,790 research outputs across all sources so far. This one has received more attention than most of these and is in the 69th percentile.
So far Altmetric has tracked 7,617 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 19.6. This one is in the 32nd percentile – i.e., 32% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 108,548 tracked outputs that were published within six weeks on either side of this one in any source. This one has gotten more attention than average, scoring higher than 66% of its contemporaries.
We're also able to compare this research output to 72 others from the same source and published within six weeks on either side of this one. This one is in the 44th percentile – i.e., 44% of its contemporaries scored the same or lower than it.