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Embryonic Stem Cell Differentiation to Functional Arterial Endothelial Cells through Sequential Activation of ETV2 and NOTCH1 Signaling by HIF1α

Overview of attention for article published in Stem Cell Reports, August 2017
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About this Attention Score

  • In the top 25% of all research outputs scored by Altmetric
  • Good Attention Score compared to outputs of the same age (77th percentile)
  • Average Attention Score compared to outputs of the same age and source

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1 blog
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1 X user
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2 Facebook pages

Citations

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76 Mendeley
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Title
Embryonic Stem Cell Differentiation to Functional Arterial Endothelial Cells through Sequential Activation of ETV2 and NOTCH1 Signaling by HIF1α
Published in
Stem Cell Reports, August 2017
DOI 10.1016/j.stemcr.2017.07.001
Pubmed ID
Authors

Kit Man Tsang, James S. Hyun, Kwong Tai Cheng, Micaela Vargas, Dolly Mehta, Masuko Ushio-Fukai, Li Zou, Kostandin V. Pajcini, Jalees Rehman, Asrar B. Malik

Abstract

The generation of functional arterial endothelial cells (aECs) from embryonic stem cells (ESCs) holds great promise for vascular tissue engineering. However, the mechanisms underlying their generation and the potential of aECs in revascularizing ischemic tissue are not fully understood. Here, we observed that hypoxia exposure of mouse ESCs induced an initial phase of HIF1α-mediated upregulation of the transcription factor Etv2, which in turn induced the commitment to the EC fate. However, sustained activation of HIF1α in these EC progenitors thereafter induced NOTCH1 signaling that promoted the transition to aEC fate. We observed that transplantation of aECs mediated arteriogenesis in the mouse hindlimb ischemia model. Furthermore, transplantation of aECs in mice showed engraftment in ischemic myocardium and restored cardiac function in contrast to ECs derived under normoxia. Thus, HIF1α activation of Etv2 in ESCs followed by NOTCH1 signaling is required for the generation aECs that are capable of arteriogenesis and revascularization of ischemic tissue.

X Demographics

X Demographics

The data shown below were collected from the profile of 1 X user who shared this research output. Click here to find out more about how the information was compiled.
Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 76 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 76 100%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 20 26%
Researcher 10 13%
Student > Master 10 13%
Student > Bachelor 5 7%
Student > Doctoral Student 3 4%
Other 10 13%
Unknown 18 24%
Readers by discipline Count As %
Biochemistry, Genetics and Molecular Biology 27 36%
Agricultural and Biological Sciences 10 13%
Medicine and Dentistry 9 12%
Engineering 5 7%
Nursing and Health Professions 1 1%
Other 4 5%
Unknown 20 26%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 8. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 07 October 2017.
All research outputs
#4,370,994
of 25,382,440 outputs
Outputs from Stem Cell Reports
#1,144
of 2,142 outputs
Outputs of similar age
#71,482
of 327,246 outputs
Outputs of similar age from Stem Cell Reports
#38
of 67 outputs
Altmetric has tracked 25,382,440 research outputs across all sources so far. Compared to these this one has done well and is in the 82nd percentile: it's in the top 25% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 2,142 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 25.4. This one is in the 45th percentile – i.e., 45% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 327,246 tracked outputs that were published within six weeks on either side of this one in any source. This one has done well, scoring higher than 77% of its contemporaries.
We're also able to compare this research output to 67 others from the same source and published within six weeks on either side of this one. This one is in the 43rd percentile – i.e., 43% of its contemporaries scored the same or lower than it.