| Title |
A pilot study for texture analysis of 18F-FDG and 18F-FLT-PET/CT to predict tumor recurrence of patients with colorectal cancer who received surgery
|
|---|---|
| Published in |
European Journal of Nuclear Medicine and Molecular Imaging, August 2017
|
| DOI | 10.1007/s00259-017-3787-0 |
| Pubmed ID | |
| Authors |
Masatoyo Nakajo, Yoriko Kajiya, Atsushi Tani, Megumi Jinguji, Masayuki Nakajo, Masaki Kitazono, Takashi Yoshiura |
| Abstract |
This retrospective study was done to examine whether the heterogeneity in primary tumor F-18-fluorodeoxyglucose ((18)F-FDG) and (18)F-3'-fluoro-3'-deoxythymidine ((18)F-FLT) distribution can predict prognosis of patients with colorectal cancer who received surgery. The enrolled 32 patients with colorectal cancer underwent both (18)F-FDG- and (18)F-FLT-PET/CT studies before surgery. Clinicopathological factors, stage, SUVmax, SUVmean, metabolic tumor volume (SUV ≥ 2.5), total lesion glycolysis, total lesion proliferation and seven texture heterogeneity parameters (coefficient of variation, local parameters: entropy, homogeneity, and dissimilarity; and regional parameters: intensity variability [IV], size-zone variability [SZV], and zone percentage [ZP]) were obtained. Progression free survival (PFS) was calculated by the Kaplan-Meier method. Prognostic significance was assessed by Cox proportional hazards analysis. Eight patients had eventually come to progression, and 24 patients were alive without progression during clinical follow-up [mean follow-up PFS; 55.9 months (range, 1-72)]. High stage (p = 0.004), high (18)F-FDG-IV (p = 0.015), high (18)F-FDG-SZV (p = 0.013) and high (18)F-FLT-entropy (p = 0.015) were significant in predicting poor 5-year PFS. Other parameters did not predict the disease outcome. At bivariate analysis, disease event hazards ratios for (18)F-FDG-IV and (18)F-FDG-SZV remained significant when adjusted for stage and (18)F-FLT-entropy ((18)F-FDG-IV; p = 0.004 [adjusted for stage], 0.007 [adjusted for (18)F-FLT-entropy]; (18)F-FDG-SZV; p = 0.028 [adjusted for stage], 0.040 [adjusted for (18)F-FLT-entropy]). (18)F-FDG PET heterogeneity parameters, IV and SZV, have a potential to be strong prognostic factors to predict PFS of patients with surgically resected colorectal cancer and are more useful than (18)F-FLT-PET/CT heterogeneity parameters. |
X Demographics
The data shown below were collected from the profile of 1 X user who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 1 | 100% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 1 | 100% |
Mendeley readers
The data shown below were compiled from readership statistics for 26 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 26 | 100% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 3 | 12% |
| Other | 3 | 12% |
| Student > Master | 3 | 12% |
| Student > Doctoral Student | 2 | 8% |
| Researcher | 2 | 8% |
| Other | 5 | 19% |
| Unknown | 8 | 31% |
| Readers by discipline | Count | As % |
|---|---|---|
| Medicine and Dentistry | 16 | 62% |
| Computer Science | 1 | 4% |
| Physics and Astronomy | 1 | 4% |
| Engineering | 1 | 4% |
| Unknown | 7 | 27% |
Attention Score in Context
This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 06 August 2017.
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#21,153,429
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Outputs from European Journal of Nuclear Medicine and Molecular Imaging
#2,610
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Outputs of similar age from European Journal of Nuclear Medicine and Molecular Imaging
#32
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