| Title |
The invasome of Salmonella Dublin as revealed by whole genome sequencing
|
|---|---|
| Published in |
BMC Infectious Diseases, August 2017
|
| DOI | 10.1186/s12879-017-2628-x |
| Pubmed ID | |
| Authors |
Manal Mohammed, Simon Le Hello, Pimlapas Leekitcharoenphon, Rene Hendriksen |
| Abstract |
Salmonella enterica serovar Dublin is a zoonotic infection that can be transmitted from cattle to humans through consumption of contaminated milk and milk products. Outbreaks of human infections by S. Dublin have been reported in several countries including high-income countries. A high proportion of S. Dublin cases in humans are associated with invasive disease and systemic illness. The genetic basis of virulence in S. Dublin is not well characterized. Whole genome sequencing was applied to a set of clinical invasive and non-invasive S. Dublin isolates from different countries in order to characterize the putative genetic determinants involved in the virulence and invasiveness of S. Dublin in humans. We identified several virulence factors that form the bacterial invasome and may contribute to increasing bacterial virulence and pathogenicity including mainly Gifsy-2 prophage, two different type 6 secretion systems (T6SSs) harbored by Salmonella pathogenicity islands; SPI-6 and SPI-19 respectively and virulence genes; ggt and PagN. Although Vi antigen and the virulence plasmid have been reported previously to contribute to the virulence of S. Dublin we did not detect them in all invasive isolates indicating that they are not the main virulence determinants in S. Dublin. Several virulence factors within the genome of S. Dublin might contribute to the ability of S. Dublin to invade humans' blood but there were no genomic markers that differentiate invasive from non-invasive isolates suggesting that host immune response play a crucial role in the clinical outcome of S. Dublin infection. |
X Demographics
The data shown below were collected from the profiles of 5 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Sweden | 1 | 20% |
| Venezuela, Bolivarian Republic of | 1 | 20% |
| Unknown | 3 | 60% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Scientists | 3 | 60% |
| Members of the public | 1 | 20% |
| Practitioners (doctors, other healthcare professionals) | 1 | 20% |
Mendeley readers
The data shown below were compiled from readership statistics for 77 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 77 | 100% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 14 | 18% |
| Student > Master | 12 | 16% |
| Researcher | 9 | 12% |
| Student > Bachelor | 8 | 10% |
| Professor | 3 | 4% |
| Other | 10 | 13% |
| Unknown | 21 | 27% |
| Readers by discipline | Count | As % |
|---|---|---|
| Veterinary Science and Veterinary Medicine | 13 | 17% |
| Agricultural and Biological Sciences | 13 | 17% |
| Biochemistry, Genetics and Molecular Biology | 9 | 12% |
| Immunology and Microbiology | 6 | 8% |
| Medicine and Dentistry | 3 | 4% |
| Other | 8 | 10% |
| Unknown | 25 | 32% |
Attention Score in Context
This research output has an Altmetric Attention Score of 3. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 19 December 2017.
All research outputs
#13,051,532
of 22,996,001 outputs
Outputs from BMC Infectious Diseases
#3,049
of 7,718 outputs
Outputs of similar age
#150,439
of 317,469 outputs
Outputs of similar age from BMC Infectious Diseases
#67
of 163 outputs
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We're also able to compare this research output to 163 others from the same source and published within six weeks on either side of this one. This one has gotten more attention than average, scoring higher than 57% of its contemporaries.