| Title |
Comparison of hybrid 68Ga-PSMA-PET/CT and 99mTc-DPD-SPECT/CT for the detection of bone metastases in prostate cancer patients: Additional value of morphologic information from low dose CT
|
|---|---|
| Published in |
European Radiology, August 2017
|
| DOI | 10.1007/s00330-017-4994-6 |
| Pubmed ID | |
| Authors |
Jan-Carlo Janssen, Sebastian Meißner, Nadine Woythal, Vikas Prasad, Winfried Brenner, Gerd Diederichs, Bernd Hamm, Marcus R. Makowski |
| Abstract |
This study compared (68)Gallium-prostate-specific-membrane-antigen based Positron-emission-tomography ((68)Ga-PSMA-PET) and (99metastable)technetium-3,3-diphospho-1,2-propanedicarbonacid ((99m)Tc-DPD-SPECT) in performing skeletal staging in prostate cancer (PC) patients and evaluated the additional value of the information from low-dose-computed tomography (CT). In this retrospective study, 54 patients who received (68)Ga-PSMA-PET/CT and (99m)Tc-DPD-SPECT/CT within 80 days were extracted from our database. Osseous lesions were classified as benign, malignant or equivocal. Lesion, region and patient based analysis was performed with and without CT fusion. The reference standard was generated by defining a best valuable comparator (BVC) containing information from all available data. In the patient based analysis, accuracies measured as "area-under-the-curve" (AUC) for (68)Ga-PSMA-PET, (99m)Tc-SPECT, (68)Ga-PSMA-PET/CT and (99m)Tc-SPECT/CT were 0.97-0.96, 0.86-0.83, 1.00 and 0.83, respectively (p<0.05) (ranges = optimistic vs. pessimistic view). Region based analysis resulted in the following sensitivities and specificities: 91.8-97.7%, 100-99.5% (PET); 61.2-70.6%, 99.8-98.3% (SPECT); 97.7%, 100% (PET/CT), 69.4% and 98.3% (SPECT/CT) (p<0.05). The amount of correct classifications of equivocal lesions by CT was significantly higher in PET (100%) compared to SPECT (52.4%) (p<0.05). (68)Ga-PSMA-PET outperforms (99m)Tc-DPD-SPECT in detecting bone metastases in PC patients. Additional information from low-dose-CT resulted in a significant reduction in equivocal lesions in both modalities, however (68)Ga-PSMA-PET benefited most. • Ga-PSMA-PET outperforms (99m) Tc-DPD-SPECT in skeletal staging in prostate cancer patients • Proportion of equivocal decisions was significantly reduced by CT-fusion in both modalities • Ga-PSMA-PET benefits more from CT information, compared to (99m) Tc-DPD-SPECT. |
X Demographics
The data shown below were collected from the profiles of 2 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 1 | 50% |
| Unknown | 1 | 50% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 1 | 50% |
| Scientists | 1 | 50% |
Mendeley readers
The data shown below were compiled from readership statistics for 62 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 62 | 100% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Researcher | 17 | 27% |
| Student > Master | 7 | 11% |
| Student > Bachelor | 6 | 10% |
| Student > Ph. D. Student | 5 | 8% |
| Student > Doctoral Student | 3 | 5% |
| Other | 9 | 15% |
| Unknown | 15 | 24% |
| Readers by discipline | Count | As % |
|---|---|---|
| Medicine and Dentistry | 27 | 44% |
| Engineering | 2 | 3% |
| Nursing and Health Professions | 1 | 2% |
| Agricultural and Biological Sciences | 1 | 2% |
| Computer Science | 1 | 2% |
| Other | 11 | 18% |
| Unknown | 19 | 31% |
Attention Score in Context
This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 14 August 2017.
All research outputs
#18,566,650
of 22,996,001 outputs
Outputs from European Radiology
#2,964
of 4,167 outputs
Outputs of similar age
#243,135
of 317,469 outputs
Outputs of similar age from European Radiology
#52
of 64 outputs
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