Title |
High-Density Lipoprotein Cholesterol Level Relates to Working Memory, Immediate and Delayed Cued Recall in Brazilian Older Adults: The Role of Cognitive Reserve
|
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Published in |
Dementia and Geriatric Cognitive Disorders, July 2017
|
DOI | 10.1159/000477846 |
Pubmed ID | |
Authors |
Andreas Ihle, Élvio R. Gouveia, Bruna R. Gouveia, Duarte L. Freitas, Jefferson Jurema, Maria A. Tinôco, Matthias Kliegel |
Abstract |
The present study set out to investigate the relation of the high-density lipoprotein cholesterol (HDL-C) level to cognitive performance and its interplay with key markers of cognitive reserve in a large sample of older adults. We assessed tests of working memory, immediate and delayed cued recall in 701 older adults from Amazonas, Brazil. The HDL-C level was derived from fasting blood samples. In addition, we interviewed individuals on their education, past occupation, and cognitive leisure activity. A critically low HDL-C level (<40 mg/dL) was significantly related to lower performance in working memory, immediate and delayed cued recall. Moderation analyses suggested that the relations of the HDL-C level to working memory and delayed cued recall were negligible in individuals with longer education, a higher cognitive level of the job, and greater engagement in cognitive leisure activity. Cognitive reserve accumulated during the life course may reduce the detrimental influences of a critically low HDL-C level on cognitive functioning in old age. |
Mendeley readers
Geographical breakdown
Country | Count | As % |
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Unknown | 54 | 100% |
Demographic breakdown
Readers by professional status | Count | As % |
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Student > Master | 8 | 15% |
Student > Ph. D. Student | 5 | 9% |
Student > Doctoral Student | 4 | 7% |
Student > Bachelor | 4 | 7% |
Researcher | 3 | 6% |
Other | 8 | 15% |
Unknown | 22 | 41% |
Readers by discipline | Count | As % |
---|---|---|
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Medicine and Dentistry | 4 | 7% |
Nursing and Health Professions | 4 | 7% |
Social Sciences | 3 | 6% |
Computer Science | 2 | 4% |
Other | 9 | 17% |
Unknown | 25 | 46% |