| Title |
The Identification of Calcified Coronary Plaque Is Associated With Initiation and Continuation of Pharmacological and Lifestyle Preventive Therapies A Systematic Review and Meta-Analysis
|
|---|---|
| Published in |
JACC: Cardiovascular Imaging, August 2017
|
| DOI | 10.1016/j.jcmg.2017.01.030 |
| Pubmed ID | |
| Authors |
Ankur Gupta, Emily Lau, Ravi Varshney, Edward A. Hulten, Michael Cheezum, Marcio S. Bittencourt, Michael J. Blaha, Nathan D. Wong, Roger S. Blumenthal, Matthew J. Budoff, Craig A. Umscheid, Khurram Nasir, Ron Blankstein |
| Abstract |
The aim of this study was to assess the odds of initiation or continuation of pharmacological and lifestyle preventive therapies in patients with nonzero versus zero coronary artery calcium (CAC) score detected on cardiac computed tomography. Detection of calcified coronary plaque could serve as a motivational tool for physicians and patients to intensify preventive therapies. We searched PubMed, EMBASE (Excerpta Medica database), Web of Science, Cochrane CENTRAL (Cochrane central register of controlled trials), ClinicalTrials.gov, and the International Clinical Trials Registry Platform for studies evaluating the association of CAC scores with downstream pharmacological or lifestyle interventions for prevention of cardiovascular disease. Pooled odds ratios (ORs) of downstream interventions were obtained using the DerSimonian and Laird random effects model. After a review of 6,256 citations and 54 full-text papers, 6 studies (11,256 participants, mean follow-up time: 1.6 to 6.0 years) were included. Pooled estimates of the odds of aspirin initiation (OR: 2.6; 95% confidence interval [CI]: 1.8 to 3.8), lipid-lowering medication initiation (OR: 2.9; 95% CI: 1.9 to 4.4), blood pressure-lowering medication initiation (OR: 1.9; 95% CI: 1.6 to 2.3), lipid-lowering medication continuation (OR: 2.3; 95% CI: 1.6 to 3.3), increase in exercise (OR: 1.8; 95% CI: 1.4 to 2.4), and dietary change (OR: 1.9; 95% CI: 1.5 to 2.5) were higher in individuals with nonzero CAC versus zero CAC scores, but not for aspirin or blood pressure-lowering medication continuation. When assessed within individual studies, these findings remained significant after adjustment for baseline patient characteristics and cardiovascular risk factors. This systematic review and meta-analysis suggests that nonzero CAC score, identifying calcified coronary plaque, significantly increases the likelihood of initiation or continuation of pharmacological and lifestyle therapies for the prevention of cardiovascular disease. |
X Demographics
The data shown below were collected from the profiles of 49 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 18 | 37% |
| Brazil | 5 | 10% |
| United Kingdom | 3 | 6% |
| Philippines | 1 | 2% |
| Netherlands | 1 | 2% |
| Colombia | 1 | 2% |
| Saudi Arabia | 1 | 2% |
| Mexico | 1 | 2% |
| France | 1 | 2% |
| Other | 0 | 0% |
| Unknown | 17 | 35% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 32 | 65% |
| Scientists | 9 | 18% |
| Practitioners (doctors, other healthcare professionals) | 5 | 10% |
| Science communicators (journalists, bloggers, editors) | 2 | 4% |
| Unknown | 1 | 2% |
Mendeley readers
The data shown below were compiled from readership statistics for 127 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 127 | 100% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Master | 18 | 14% |
| Researcher | 17 | 13% |
| Other | 11 | 9% |
| Student > Doctoral Student | 10 | 8% |
| Student > Ph. D. Student | 8 | 6% |
| Other | 26 | 20% |
| Unknown | 37 | 29% |
| Readers by discipline | Count | As % |
|---|---|---|
| Medicine and Dentistry | 51 | 40% |
| Nursing and Health Professions | 10 | 8% |
| Biochemistry, Genetics and Molecular Biology | 4 | 3% |
| Pharmacology, Toxicology and Pharmaceutical Science | 3 | 2% |
| Social Sciences | 3 | 2% |
| Other | 9 | 7% |
| Unknown | 47 | 37% |
Attention Score in Context
This research output has an Altmetric Attention Score of 71. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 08 February 2023.
All research outputs
#598,629
of 25,382,440 outputs
Outputs from JACC: Cardiovascular Imaging
#149
of 2,700 outputs
Outputs of similar age
#12,596
of 327,503 outputs
Outputs of similar age from JACC: Cardiovascular Imaging
#4
of 46 outputs
Altmetric has tracked 25,382,440 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 97th percentile: it's in the top 5% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 2,700 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 18.1. This one has done particularly well, scoring higher than 94% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 327,503 tracked outputs that were published within six weeks on either side of this one in any source. This one has done particularly well, scoring higher than 96% of its contemporaries.
We're also able to compare this research output to 46 others from the same source and published within six weeks on either side of this one. This one has done particularly well, scoring higher than 91% of its contemporaries.