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X Demographics
Mendeley readers
Attention Score in Context
| Title |
Relationships between age and late progression of Parkinson’s disease: a clinico-pathological study
|
|---|---|
| Published in |
Brain, April 2010
|
| DOI | 10.1093/brain/awq059 |
| Pubmed ID | |
| Authors |
Peter A. Kempster, Sean S. O’Sullivan, Janice L. Holton, Tamas Revesz, Andrew J. Lees |
| Abstract |
To investigate the relationships between age, the advanced clinical stages of Parkinson's disease and neuropathology, we surveyed 129 case records from donors with pathologically proven Parkinson's disease at the Queen Square Brain Bank for Neurological Disorders. Cases were separated into five groups according to age at death, thus comparing patients who reached the advanced stage of the disease at different ages. Four milestones of advanced disease (frequent falls, visual hallucinations, dementia and need for residential care) occurred at a similar time from death in each group. There were no significant differences in disease duration across these age groupings, nor were there differences in the severity and distribution of Lewy body and other pathologies. The milestones of dementia (P < 0.0005) and visual hallucinations (P = 0.02) as well as the accumulation of multiple milestones (P < 0.0005) were associated with high cortical Lewy body scores. Demented cases also had significantly more Alzheimer neurofibrillary and amyloid-beta plaque pathology. Correlation analysis showed that the time intervals between disease onset and recording of milestones were strongly influenced by age at onset (P < 0.0001) and by total disease duration (P < 0.0001). The advanced disease phase plays out in a similar fashion at whatever age it occurs, with a common pathological endpoint. The clinico-pathological comparisons for the final stage of Parkinson's disease do support a staging system based on the rostral extent and severity of Lewy body pathology, although other pathologies may play a synergistic role in causing cognitive disability. The chief effects of age on the rate of progression are seen over the early-middle part of the disease. An exponential curve for clinical progression provides the best explanation for these observations about age and the disease course. |
X Demographics
The data shown below were collected from the profiles of 3 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United Kingdom | 2 | 67% |
| United States | 1 | 33% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Practitioners (doctors, other healthcare professionals) | 2 | 67% |
| Members of the public | 1 | 33% |
Mendeley readers
The data shown below were compiled from readership statistics for 326 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United Kingdom | 4 | 1% |
| Japan | 3 | <1% |
| United States | 2 | <1% |
| France | 1 | <1% |
| Unknown | 316 | 97% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 59 | 18% |
| Researcher | 48 | 15% |
| Student > Master | 39 | 12% |
| Other | 24 | 7% |
| Student > Bachelor | 23 | 7% |
| Other | 66 | 20% |
| Unknown | 67 | 21% |
| Readers by discipline | Count | As % |
|---|---|---|
| Medicine and Dentistry | 103 | 32% |
| Neuroscience | 50 | 15% |
| Agricultural and Biological Sciences | 21 | 6% |
| Psychology | 18 | 6% |
| Biochemistry, Genetics and Molecular Biology | 17 | 5% |
| Other | 38 | 12% |
| Unknown | 79 | 24% |
Attention Score in Context
This research output has an Altmetric Attention Score of 11. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 17 May 2023.
All research outputs
#3,322,381
of 25,837,817 outputs
Outputs from Brain
#3,151
of 7,773 outputs
Outputs of similar age
#12,876
of 107,088 outputs
Outputs of similar age from Brain
#17
of 61 outputs
Altmetric has tracked 25,837,817 research outputs across all sources so far. Compared to these this one has done well and is in the 87th percentile: it's in the top 25% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 7,773 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 27.9. This one has gotten more attention than average, scoring higher than 58% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 107,088 tracked outputs that were published within six weeks on either side of this one in any source. This one has done well, scoring higher than 86% of its contemporaries.
We're also able to compare this research output to 61 others from the same source and published within six weeks on either side of this one. This one has gotten more attention than average, scoring higher than 72% of its contemporaries.