| Title |
Metabolomics approach reveals effects of antihypertensives and lipid-lowering drugs on the human metabolism
|
|---|---|
| Published in |
European Journal of Epidemiology, May 2014
|
| DOI | 10.1007/s10654-014-9910-7 |
| Pubmed ID | |
| Authors |
Elisabeth Altmaier, Gisela Fobo, Margit Heier, Barbara Thorand, Christine Meisinger, Werner Römisch-Margl, Melanie Waldenberger, Christian Gieger, Thomas Illig, Jerzy Adamski, Karsten Suhre, Gabi Kastenmüller |
| Abstract |
The mechanism of antihypertensive and lipid-lowering drugs on the human organism is still not fully understood. New insights on the drugs' action can be provided by a metabolomics-driven approach, which offers a detailed view of the physiological state of an organism. Here, we report a metabolome-wide association study with 295 metabolites in human serum from 1,762 participants of the KORA F4 (Cooperative Health Research in the Region of Augsburg) study population. Our intent was to find variations of metabolite concentrations related to the intake of various drug classes and--based on the associations found--to generate new hypotheses about on-target as well as off-target effects of these drugs. In total, we found 41 significant associations for the drug classes investigated: For beta-blockers (11 associations), angiotensin-converting enzyme (ACE) inhibitors (four assoc.), diuretics (seven assoc.), statins (ten assoc.), and fibrates (nine assoc.) the top hits were pyroglutamine, phenylalanylphenylalanine, pseudouridine, 1-arachidonoylglycerophosphocholine, and 2-hydroxyisobutyrate, respectively. For beta-blockers we observed significant associations with metabolite concentrations that are indicative of drug side-effects, such as increased serotonin and decreased free fatty acid levels. Intake of ACE inhibitors and statins associated with metabolites that provide insight into the action of the drug itself on its target, such as an association of ACE inhibitors with des-Arg(9)-bradykinin and aspartylphenylalanine, a substrate and a product of the drug-inhibited ACE. The intake of statins which reduce blood cholesterol levels, resulted in changes in the concentration of metabolites of the biosynthesis as well as of the degradation of cholesterol. Fibrates showed the strongest association with 2-hydroxyisobutyrate which might be a breakdown product of fenofibrate and, thus, a possible marker for the degradation of this drug in the human organism. The analysis of diuretics showed a heterogeneous picture that is difficult to interpret. Taken together, our results provide a basis for a deeper functional understanding of the action and side-effects of antihypertensive and lipid-lowering drugs in the general population. |
X Demographics
The data shown below were collected from the profiles of 2 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Qatar | 1 | 50% |
| United States | 1 | 50% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Scientists | 1 | 50% |
| Members of the public | 1 | 50% |
Mendeley readers
The data shown below were compiled from readership statistics for 82 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Czechia | 2 | 2% |
| Netherlands | 1 | 1% |
| Germany | 1 | 1% |
| Spain | 1 | 1% |
| Japan | 1 | 1% |
| Unknown | 76 | 93% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 17 | 21% |
| Student > Bachelor | 12 | 15% |
| Researcher | 11 | 13% |
| Student > Master | 9 | 11% |
| Other | 6 | 7% |
| Other | 14 | 17% |
| Unknown | 13 | 16% |
| Readers by discipline | Count | As % |
|---|---|---|
| Medicine and Dentistry | 17 | 21% |
| Agricultural and Biological Sciences | 12 | 15% |
| Biochemistry, Genetics and Molecular Biology | 11 | 13% |
| Pharmacology, Toxicology and Pharmaceutical Science | 7 | 9% |
| Chemistry | 5 | 6% |
| Other | 12 | 15% |
| Unknown | 18 | 22% |
Attention Score in Context
This research output has an Altmetric Attention Score of 24. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 27 June 2019.
All research outputs
#1,321,290
of 22,755,127 outputs
Outputs from European Journal of Epidemiology
#191
of 1,618 outputs
Outputs of similar age
#14,143
of 227,074 outputs
Outputs of similar age from European Journal of Epidemiology
#8
of 31 outputs
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