| Title |
Piperine Reverses Chronic Unpredictable Mild Stress-Induced Behavioral and Biochemical Alterations in Rats
|
|---|---|
| Published in |
Cellular and Molecular Neurobiology, January 2014
|
| DOI | 10.1007/s10571-014-0025-1 |
| Pubmed ID | |
| Authors |
Qing-Qiu Mao, Zhen Huang, Xiao-Ming Zhong, Yan-Fang Xian, Siu-Po Ip |
| Abstract |
Previous studies in our laboratory have demonstrated that piperine produced antidepressant-like action in various mouse models of behavioral despair, which was related to the serotonergic system. The present study aimed to examine the behavioral and biochemical effects of piperine in rats exposed to chronic unpredictable mild stress (CUMS). The results showed that CUMS caused depression-like behavior in rats, as indicated by the significant decrease in sucrose consumption and increase in immobility time in the forced swim test. In addition, it was found that serotonin (5-HT) and brain-derived neurotrophic factor (BDNF) contents in the hippocampus and frontal cortex were significantly decreased in CUMS-treated rats. Treating the animals with piperine significantly suppressed behavioral and biochemical changes induced by CUMS. The results suggest that piperine produces an antidepressant-like effect in CUMS-treated rats, which is possibly mediated by increasing 5-HT and BDNF contents in selective brain tissues. |
Mendeley readers
The data shown below were compiled from readership statistics for 35 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Brazil | 1 | 3% |
| Unknown | 34 | 97% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Master | 10 | 29% |
| Student > Bachelor | 5 | 14% |
| Student > Ph. D. Student | 5 | 14% |
| Researcher | 3 | 9% |
| Other | 1 | 3% |
| Other | 2 | 6% |
| Unknown | 9 | 26% |
| Readers by discipline | Count | As % |
|---|---|---|
| Pharmacology, Toxicology and Pharmaceutical Science | 9 | 26% |
| Medicine and Dentistry | 6 | 17% |
| Agricultural and Biological Sciences | 4 | 11% |
| Psychology | 2 | 6% |
| Neuroscience | 2 | 6% |
| Other | 0 | 0% |
| Unknown | 12 | 34% |
Attention Score in Context
This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 15 November 2016.
All research outputs
#19,382,126
of 23,854,458 outputs
Outputs from Cellular and Molecular Neurobiology
#745
of 1,046 outputs
Outputs of similar age
#236,108
of 311,994 outputs
Outputs of similar age from Cellular and Molecular Neurobiology
#6
of 10 outputs
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