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Does Tautomerization of FapyG Influence Its Mutagenicity?

Overview of attention for article published in ChemPhysChem, May 2014
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Title
Does Tautomerization of FapyG Influence Its Mutagenicity?
Published in
ChemPhysChem, May 2014
DOI 10.1002/cphc.201400045
Pubmed ID
Authors

Nihar R. Jena, Alan E. Mark, Phool C. Mishra

Abstract

Oxidative degradation of guanine to 2,6-diamino-4-oxo-5-formamidopyrimidine (FapyG) is believed to be mutagenic. It has been proposed recently that the enol tautomer of FapyG is mainly responsible for this effect leading to a guanine-to-thymine mutation (T. H. Gehrke, U. Lischke, K. L. Gasteiger, S. Schneider, S. Arnold, H. C. Muller, D. S. Stephenson, H. Zipse, T. Carell, Nat. Chem. Biol.- 2013, 9, 455-461). Here, density functional methods suggest that the enol tautomer of FapyG might not be responsible for the proposed guanine-to-thymine mutation. Instead, it might result in a guanine-to-adenine mutation.

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X Demographics

The data shown below were collected from the profile of 1 X user who shared this research output. Click here to find out more about how the information was compiled.
Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 10 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 10 100%

Demographic breakdown

Readers by professional status Count As %
Professor 4 40%
Student > Ph. D. Student 1 10%
Professor > Associate Professor 1 10%
Unknown 4 40%
Readers by discipline Count As %
Chemistry 4 40%
Biochemistry, Genetics and Molecular Biology 1 10%
Pharmacology, Toxicology and Pharmaceutical Science 1 10%
Unknown 4 40%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 14 May 2014.
All research outputs
#20,039,697
of 24,629,540 outputs
Outputs from ChemPhysChem
#2,916
of 5,151 outputs
Outputs of similar age
#169,900
of 232,118 outputs
Outputs of similar age from ChemPhysChem
#31
of 117 outputs
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So far Altmetric has tracked 5,151 research outputs from this source. They receive a mean Attention Score of 2.3. This one is in the 5th percentile – i.e., 5% of its peers scored the same or lower than it.
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We're also able to compare this research output to 117 others from the same source and published within six weeks on either side of this one. This one is in the 1st percentile – i.e., 1% of its contemporaries scored the same or lower than it.