| Title |
Moderate endurance training (marathon-training) – effects on immunologic and metabolic parameters in HIV-infected patients: the 42 KM cologne project
|
|---|---|
| Published in |
BMC Infectious Diseases, August 2017
|
| DOI | 10.1186/s12879-017-2651-y |
| Pubmed ID | |
| Authors |
Stefan Schlabe, Martin Vogel, Christoph Boesecke, Carolynne Schwarze-Zander, Jürgen K. Rockstroh, Christian Körner, Klara Brixius, Jan-Christian Wasmuth |
| Abstract |
Improved treatment options of HIV have resulted in regular physical activities of many HIV-infected patients. However, data on effects of sports in HIV-patients are scarce. 21 HIV-infected persons were monitored prospectively while preparing for a marathon run. Multiple parameters with regard to immunology, quality of life and metabolism were measured at 4 time points (at baseline 1 year before the marathon run, 3 and 6 months after beginning of training, and immediately before marathon). 13 out of 21 participants completed the marathon (12 male, 1 female; median age 42 years [27-50]; CD4 = 620/μl [146-1268]; 11 were on ART since 3.5 years [1-7]). 8 participants ceased training early. All reasons for stopping (besides one pre-existing metatarsal fracture) were not regarded as training-related (e.g. time limitation n = 3; newly diagnosed anal cancer n = 1; personal reasons/unknown n = 3). We observed a significant increase in absolute CD4-T-cells (620/μl [146-1268] vs. 745 [207-1647]; p = 0.001) with simultaneous decrease of CD4-T-cell apoptosis (53% [47-64] vs. 32% [14-42]); p < 0.01). No effects on viral load independent of ART occurred. Systolic blood pressure and cholesterol improved significantly, although moderate and normal at baseline (cholesterol 185 mg/dl [98-250] vs. 167 [106-222], p = 0.02; RRsys 125 mmHg [100-145] vs. 120 [100-140], p = 0.01). Blood count, liver enzymes, creatinine and CK remained unchanged. The results of this pilot study indicated improved metabolic and immunologic parameters in HIV-infected patients undergoing moderate endurance training. Although training effects or ART cannot be ultimately separated as underlying mechanisms, we conclude that marathon training is safe for HIV-infected patients and potentially improves general health. DRKS00011592 (retrospectively registered on February 9th 2017). |
X Demographics
The data shown below were collected from the profiles of 11 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United Kingdom | 5 | 45% |
| Uganda | 2 | 18% |
| Netherlands | 2 | 18% |
| Australia | 1 | 9% |
| United States | 1 | 9% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 5 | 45% |
| Scientists | 5 | 45% |
| Practitioners (doctors, other healthcare professionals) | 1 | 9% |
Mendeley readers
The data shown below were compiled from readership statistics for 86 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 86 | 100% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Master | 16 | 19% |
| Student > Bachelor | 10 | 12% |
| Student > Ph. D. Student | 8 | 9% |
| Researcher | 6 | 7% |
| Other | 6 | 7% |
| Other | 10 | 12% |
| Unknown | 30 | 35% |
| Readers by discipline | Count | As % |
|---|---|---|
| Medicine and Dentistry | 23 | 27% |
| Nursing and Health Professions | 12 | 14% |
| Sports and Recreations | 11 | 13% |
| Biochemistry, Genetics and Molecular Biology | 2 | 2% |
| Psychology | 2 | 2% |
| Other | 5 | 6% |
| Unknown | 31 | 36% |
Attention Score in Context
This research output has an Altmetric Attention Score of 7. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 02 February 2020.
All research outputs
#4,474,904
of 22,996,001 outputs
Outputs from BMC Infectious Diseases
#1,441
of 7,718 outputs
Outputs of similar age
#78,396
of 317,853 outputs
Outputs of similar age from BMC Infectious Diseases
#25
of 164 outputs
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