Title |
Mitotic Wnt Signaling Promotes Protein Stabilization and Regulates Cell Size
|
---|---|
Published in |
Molecular Cell, May 2014
|
DOI | 10.1016/j.molcel.2014.04.014 |
Pubmed ID | |
Authors |
Sergio P. Acebron, Emil Karaulanov, Birgit S. Berger, Ya-Lin Huang, Christof Niehrs |
Abstract |
Canonical Wnt signaling is thought to regulate cell behavior mainly by inducing β-catenin-dependent transcription of target genes. In proliferating cells Wnt signaling peaks in the G2/M phase of the cell cycle, but the significance of this "mitotic Wnt signaling" is unclear. Here we introduce Wnt-dependent stabilization of proteins (Wnt/STOP), which is independent of β-catenin and peaks during mitosis. We show that Wnt/STOP plays a critical role in protecting proteins, including c-MYC, from GSK3-dependent polyubiquitination and degradation. Wnt/STOP signaling increases cellular protein levels and cell size. Wnt/STOP, rather than β-catenin signaling, is the dominant mode of Wnt signaling in several cancer cell lines, where it is required for cell growth. We propose that Wnt/STOP signaling slows down protein degradation as cells prepare to divide. |
X Demographics
Geographical breakdown
Country | Count | As % |
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United Kingdom | 1 | 33% |
Unknown | 2 | 67% |
Demographic breakdown
Type | Count | As % |
---|---|---|
Members of the public | 2 | 67% |
Science communicators (journalists, bloggers, editors) | 1 | 33% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
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Portugal | 1 | <1% |
Germany | 1 | <1% |
Chile | 1 | <1% |
United Kingdom | 1 | <1% |
Spain | 1 | <1% |
United States | 1 | <1% |
Unknown | 267 | 98% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Student > Ph. D. Student | 78 | 29% |
Researcher | 44 | 16% |
Student > Master | 35 | 13% |
Student > Bachelor | 26 | 10% |
Professor > Associate Professor | 10 | 4% |
Other | 34 | 12% |
Unknown | 46 | 17% |
Readers by discipline | Count | As % |
---|---|---|
Agricultural and Biological Sciences | 94 | 34% |
Biochemistry, Genetics and Molecular Biology | 84 | 31% |
Medicine and Dentistry | 14 | 5% |
Chemistry | 6 | 2% |
Neuroscience | 5 | 2% |
Other | 21 | 8% |
Unknown | 49 | 18% |