Title |
Prevention of congenital malformations and other adverse pregnancy outcomes with 4.0 mg of folic acid: community-based randomized clinical trial in Italy and the Netherlands
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Published in |
BMC Pregnancy and Childbirth, May 2014
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DOI | 10.1186/1471-2393-14-166 |
Pubmed ID | |
Authors |
Renata Bortolus, Fenneke Blom, Francesca Filippini, Mireille NM van Poppel, Emanuele Leoncini, Denhard J de Smit, Pier Paolo Benetollo, Martina C Cornel, Hermien EK de Walle, Pierpaolo Mastroiacovo |
Abstract |
In 2010 a Cochrane review confirmed that folic acid (FA) supplementation prevents the first- and second-time occurrence of neural tube defects (NTDs). At present some evidence from observational studies supports the hypothesis that FA supplementation can reduce the risk of all congenital malformations (CMs) or the risk of a specific and selected group of them, namely cardiac defects and oral clefts. Furthermore, the effects on the prevention of prematurity, foetal growth retardation and pre-eclampsia are unclear.Although the most common recommendation is to take 0.4 mg/day, the problem of the most appropriate dose of FA is still open.The aim of this project is to assess the effect a higher dose of peri-conceptional FA supplementation on reducing the occurrence of all CMs. Other aims include the promotion of pre-conceptional counselling, comparing rates of selected CMs, miscarriage, pre-eclampsia, preterm birth, small for gestational age, abruptio placentae. |
X Demographics
Geographical breakdown
Country | Count | As % |
---|---|---|
Netherlands | 1 | 33% |
Ireland | 1 | 33% |
Unknown | 1 | 33% |
Demographic breakdown
Type | Count | As % |
---|---|---|
Members of the public | 3 | 100% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
United Kingdom | 1 | <1% |
Canada | 1 | <1% |
Australia | 1 | <1% |
Egypt | 1 | <1% |
Unknown | 249 | 98% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Student > Bachelor | 38 | 15% |
Researcher | 29 | 11% |
Student > Master | 29 | 11% |
Student > Ph. D. Student | 19 | 8% |
Student > Doctoral Student | 13 | 5% |
Other | 52 | 21% |
Unknown | 73 | 29% |
Readers by discipline | Count | As % |
---|---|---|
Medicine and Dentistry | 88 | 35% |
Nursing and Health Professions | 23 | 9% |
Biochemistry, Genetics and Molecular Biology | 12 | 5% |
Agricultural and Biological Sciences | 12 | 5% |
Psychology | 8 | 3% |
Other | 34 | 13% |
Unknown | 76 | 30% |