| Title |
Three-dimensional polymer coated 45S5-type bioactive glass scaffolds seeded with human mesenchymal stem cells show bone formation in vivo
|
|---|---|
| Published in |
Journal of Materials Science: Materials in Medicine, June 2016
|
| DOI | 10.1007/s10856-016-5732-3 |
| Pubmed ID | |
| Authors |
Fabian Westhauser, Christian Weis, Matthäus Prokscha, Leonie A. Bittrich, Wei Li, Kai Xiao, Ulrich Kneser, Hans-Ulrich Kauczor, Gerhard Schmidmaier, Aldo R. Boccaccini, Arash Moghaddam |
| Abstract |
45S5-type bioactive glasses are a promising alternative to established substitutes for the treatment of bone defects. Because the three-dimensional (3D) structure of bone substitutes is crucial for bone ingrowth and formation, we evaluated the osteoinductive properties of different polymer coated 3D-45S5 bioactive glass (BG) scaffolds seeded with human mesenchymal stem cells (hMSC) in vivo. BG scaffolds coated with gelatin, cross-linked gelatin, and poly(3-hydroxybutyrate-co-3-hydroxyvalerate) were seeded with hMSC prior to implantation into severe combined immunodeficiency mice. Newly formed bone was evaluated with histomorphometry and micro-computed tomography. Bone formation was detectable in all groups, whereas the gelatin-coated BG scaffolds showed the best results and should be considered in further studies. |
Mendeley readers
The data shown below were compiled from readership statistics for 84 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Chile | 1 | 1% |
| China | 1 | 1% |
| Unknown | 82 | 98% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Master | 15 | 18% |
| Student > Ph. D. Student | 13 | 15% |
| Researcher | 9 | 11% |
| Student > Bachelor | 7 | 8% |
| Other | 6 | 7% |
| Other | 14 | 17% |
| Unknown | 20 | 24% |
| Readers by discipline | Count | As % |
|---|---|---|
| Materials Science | 18 | 21% |
| Engineering | 15 | 18% |
| Medicine and Dentistry | 15 | 18% |
| Biochemistry, Genetics and Molecular Biology | 4 | 5% |
| Chemical Engineering | 3 | 4% |
| Other | 6 | 7% |
| Unknown | 23 | 27% |
Attention Score in Context
This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 07 August 2017.
All research outputs
#20,442,790
of 22,997,544 outputs
Outputs from Journal of Materials Science: Materials in Medicine
#1,294
of 1,406 outputs
Outputs of similar age
#294,284
of 341,634 outputs
Outputs of similar age from Journal of Materials Science: Materials in Medicine
#9
of 13 outputs
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