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X Demographics
Mendeley readers
Attention Score in Context
| Title |
A genome-wide association study identifies new psoriasis susceptibility loci and an interaction between HLA-C and ERAP1
|
|---|---|
| Published in |
Nature Genetics, October 2010
|
| DOI | 10.1038/ng.694 |
| Pubmed ID | |
| Abstract |
To identify new susceptibility loci for psoriasis, we undertook a genome-wide association study of 594,224 SNPs in 2,622 individuals with psoriasis and 5,667 controls. We identified associations at eight previously unreported genomic loci. Seven loci harbored genes with recognized immune functions (IL28RA, REL, IFIH1, ERAP1, TRAF3IP2, NFKBIA and TYK2). These associations were replicated in 9,079 European samples (six loci with a combined P < 5 × 10⁻⁸ and two loci with a combined P < 5 × 10⁻⁷). We also report compelling evidence for an interaction between the HLA-C and ERAP1 loci (combined P = 6.95 × 10⁻⁶). ERAP1 plays an important role in MHC class I peptide processing. ERAP1 variants only influenced psoriasis susceptibility in individuals carrying the HLA-C risk allele. Our findings implicate pathways that integrate epidermal barrier dysfunction with innate and adaptive immune dysregulation in psoriasis pathogenesis. |
X Demographics
The data shown below were collected from the profiles of 3 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Russia | 1 | 33% |
| Unknown | 2 | 67% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 3 | 100% |
Mendeley readers
The data shown below were compiled from readership statistics for 474 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 8 | 2% |
| United Kingdom | 6 | 1% |
| France | 2 | <1% |
| Australia | 2 | <1% |
| Germany | 2 | <1% |
| Ireland | 1 | <1% |
| Denmark | 1 | <1% |
| Hungary | 1 | <1% |
| Japan | 1 | <1% |
| Other | 1 | <1% |
| Unknown | 449 | 95% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Researcher | 112 | 24% |
| Student > Ph. D. Student | 88 | 19% |
| Student > Master | 43 | 9% |
| Student > Bachelor | 30 | 6% |
| Other | 26 | 5% |
| Other | 89 | 19% |
| Unknown | 86 | 18% |
| Readers by discipline | Count | As % |
|---|---|---|
| Agricultural and Biological Sciences | 141 | 30% |
| Medicine and Dentistry | 98 | 21% |
| Biochemistry, Genetics and Molecular Biology | 60 | 13% |
| Immunology and Microbiology | 24 | 5% |
| Pharmacology, Toxicology and Pharmaceutical Science | 12 | 3% |
| Other | 41 | 9% |
| Unknown | 98 | 21% |
Attention Score in Context
This research output has an Altmetric Attention Score of 32. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 20 March 2024.
All research outputs
#1,218,937
of 25,196,456 outputs
Outputs from Nature Genetics
#1,941
of 7,547 outputs
Outputs of similar age
#3,782
of 105,815 outputs
Outputs of similar age from Nature Genetics
#9
of 50 outputs
Altmetric has tracked 25,196,456 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 95th percentile: it's in the top 5% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 7,547 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 43.0. This one has gotten more attention than average, scoring higher than 74% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 105,815 tracked outputs that were published within six weeks on either side of this one in any source. This one has done particularly well, scoring higher than 96% of its contemporaries.
We're also able to compare this research output to 50 others from the same source and published within six weeks on either side of this one. This one has done well, scoring higher than 84% of its contemporaries.