| Title |
T Cell Populations and Functions Are Altered in Human Obesity and Type 2 Diabetes
|
|---|---|
| Published in |
Current Diabetes Reports, August 2017
|
| DOI | 10.1007/s11892-017-0900-5 |
| Pubmed ID | |
| Authors |
Sothea Touch, Karine Clément, Sébastien André |
| Abstract |
Obesity and type 2 diabetes (T2D) are considered chronic inflammatory diseases. While early publications have reported the implication of innate immune cells such as macrophages to promote systemic inflammation and metabolic dysfunctions, recent publications underline the alterations of the T cell compartment in human obesity and type 2 diabetes. These recent findings are the focus of this review. In humans, obesity and T2D induce the expansion of proinflammatory T cells such as CD4 Th1, Th17, and CD8 populations, whereas innate T cells such as MAIT and iNKT cells are decreased. These alterations reflect a loss of total T cell homeostasis that may contribute to tissue and systemic inflammation. Whether these changes are adaptive to nutritional variations and/or contribute to the progression of metabolic diseases remains to be clarified. T cell phenotyping may improve obese and/or T2D patient stratification with therapeutic and prognostic implications. |
X Demographics
The data shown below were collected from the profiles of 2 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United Kingdom | 1 | 50% |
| France | 1 | 50% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Science communicators (journalists, bloggers, editors) | 1 | 50% |
| Practitioners (doctors, other healthcare professionals) | 1 | 50% |
Mendeley readers
The data shown below were compiled from readership statistics for 96 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 96 | 100% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 17 | 18% |
| Student > Master | 16 | 17% |
| Researcher | 11 | 11% |
| Student > Bachelor | 11 | 11% |
| Student > Doctoral Student | 4 | 4% |
| Other | 14 | 15% |
| Unknown | 23 | 24% |
| Readers by discipline | Count | As % |
|---|---|---|
| Biochemistry, Genetics and Molecular Biology | 26 | 27% |
| Immunology and Microbiology | 12 | 13% |
| Agricultural and Biological Sciences | 11 | 11% |
| Medicine and Dentistry | 9 | 9% |
| Nursing and Health Professions | 2 | 2% |
| Other | 7 | 7% |
| Unknown | 29 | 30% |
Attention Score in Context
This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 25 August 2017.
All research outputs
#15,826,468
of 23,510,717 outputs
Outputs from Current Diabetes Reports
#663
of 1,021 outputs
Outputs of similar age
#200,807
of 318,421 outputs
Outputs of similar age from Current Diabetes Reports
#23
of 29 outputs
Altmetric has tracked 23,510,717 research outputs across all sources so far. This one is in the 22nd percentile – i.e., 22% of other outputs scored the same or lower than it.
So far Altmetric has tracked 1,021 research outputs from this source. They typically receive more attention than average, with a mean Attention Score of 8.4. This one is in the 25th percentile – i.e., 25% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 318,421 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 28th percentile – i.e., 28% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 29 others from the same source and published within six weeks on either side of this one. This one is in the 20th percentile – i.e., 20% of its contemporaries scored the same or lower than it.