Title |
Successful use of equine anti-thymocyte globulin (ATGAM) for fulminant myocarditis secondary to nivolumab therapy
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Published in |
British Journal of Cancer, August 2017
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DOI | 10.1038/bjc.2017.253 |
Pubmed ID | |
Authors |
Rebecca Y Tay, Elizabeth Blackley, Catriona McLean, Maggie Moore, Peter Bergin, Sanjeev Gill, Andrew Haydon |
Abstract |
Immune-mediated myocarditis is an uncommon adverse effect of immune checkpoint inhibition and is associated with a high rate of mortality. In this reported case, a 64-year-old woman with right temporo-parietal glioblastoma IDH-WT was treated with nivolumab, temozolomide and radiation therapy on a clinical trial. She developed malignant arrhythmias secondary to histologically confirmed severe immune-mediated myocarditis. She was treated with equine anti-thymocyte globulin (ATGAM) due to development of malignant arrhythmias refractory to high-dose corticosteroids. This report describes the only case of immune-mediated myocarditis treated with ATGAM resulting in a favourable outcome. Use of ATGAM should be considered in cases of steroid-refractory immune-mediated myocarditis and administered in close consultation with a cardiac transplant team experienced in the use of this agent.British Journal of Cancer advance online publication: 10 August 2017; doi:10.1038/bjc.2017.253 www.bjcancer.com. |
X Demographics
Geographical breakdown
Country | Count | As % |
---|---|---|
France | 2 | 17% |
Canada | 1 | 8% |
United States | 1 | 8% |
Spain | 1 | 8% |
Unknown | 7 | 58% |
Demographic breakdown
Type | Count | As % |
---|---|---|
Members of the public | 10 | 83% |
Practitioners (doctors, other healthcare professionals) | 1 | 8% |
Scientists | 1 | 8% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
Unknown | 70 | 100% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Other | 10 | 14% |
Researcher | 7 | 10% |
Student > Master | 6 | 9% |
Student > Doctoral Student | 5 | 7% |
Student > Bachelor | 5 | 7% |
Other | 14 | 20% |
Unknown | 23 | 33% |
Readers by discipline | Count | As % |
---|---|---|
Medicine and Dentistry | 32 | 46% |
Unspecified | 2 | 3% |
Biochemistry, Genetics and Molecular Biology | 2 | 3% |
Engineering | 2 | 3% |
Agricultural and Biological Sciences | 1 | 1% |
Other | 6 | 9% |
Unknown | 25 | 36% |