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EPR analysis of cyanide complexes of wild-type human neuroglobin and mutants in comparison to horse heart myoglobin

Overview of attention for article published in Biophysical Chemistry, April 2014
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Title
EPR analysis of cyanide complexes of wild-type human neuroglobin and mutants in comparison to horse heart myoglobin
Published in
Biophysical Chemistry, April 2014
DOI 10.1016/j.bpc.2014.03.007
Pubmed ID
Authors

Sabine Van Doorslaer, Florin Trandafir, Jeffrey R. Harmer, Luc Moens, Sylvia Dewilde

Abstract

Electron paramagnetic resonance (EPR) data reveal large differences between the ferric ((13)C-)cyanide complexes of wild-type human neuroglobin (NGB) and its H64Q and F28L point mutants and the cyanide complexes of mammalian myo- and haemoglobin. The point mutations, which involve residues comprising the distal haem pocket in NGB, induce smaller, but still significant changes, related to changes in the stabilization of the cyanide ligand. Furthermore, for the first time, the full (13)C hyperfine tensor of the cyanide carbon of cyanide-ligated horse heart myoglobin (hhMb) was determined using Davies ENDOR (electron nuclear double resonance). Disagreement of these experimental data with earlier predictions based on (13)C NMR data and a theoretical model reveal significant flaws in the model assumptions. The same ENDOR procedure allowed also partial determination of the corresponding (13)C hyperfine tensor of cyanide-ligated NGB and H64QNGB. These (13)C parameters differ significantly from those of cyanide-ligated hhMb and challenge our current theoretical understanding of how the haem environment influences the magnetic parameters obtained by EPR and NMR in cyanide-ligated haem proteins.

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Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 16 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Israel 1 6%
Unknown 15 94%

Demographic breakdown

Readers by professional status Count As %
Professor 4 25%
Researcher 4 25%
Student > Bachelor 1 6%
Student > Master 1 6%
Student > Ph. D. Student 1 6%
Other 2 13%
Unknown 3 19%
Readers by discipline Count As %
Chemistry 5 31%
Biochemistry, Genetics and Molecular Biology 2 13%
Agricultural and Biological Sciences 2 13%
Physics and Astronomy 2 13%
Pharmacology, Toxicology and Pharmaceutical Science 1 6%
Other 0 0%
Unknown 4 25%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 19 May 2014.
All research outputs
#17,285,668
of 25,374,647 outputs
Outputs from Biophysical Chemistry
#694
of 1,179 outputs
Outputs of similar age
#145,514
of 241,522 outputs
Outputs of similar age from Biophysical Chemistry
#2
of 4 outputs
Altmetric has tracked 25,374,647 research outputs across all sources so far. This one is in the 21st percentile – i.e., 21% of other outputs scored the same or lower than it.
So far Altmetric has tracked 1,179 research outputs from this source. They receive a mean Attention Score of 2.9. This one is in the 35th percentile – i.e., 35% of its peers scored the same or lower than it.
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We're also able to compare this research output to 4 others from the same source and published within six weeks on either side of this one. This one has scored higher than 2 of them.