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Apple Derived Cellulose Scaffolds for 3D Mammalian Cell Culture

Overview of attention for article published in PLOS ONE, May 2014
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About this Attention Score

  • In the top 5% of all research outputs scored by Altmetric
  • High Attention Score compared to outputs of the same age (98th percentile)
  • High Attention Score compared to outputs of the same age and source (97th percentile)

Mentioned by

news
7 news outlets
blogs
2 blogs
twitter
34 X users
patent
7 patents
facebook
1 Facebook page
video
1 YouTube creator

Citations

dimensions_citation
162 Dimensions

Readers on

mendeley
486 Mendeley
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Title
Apple Derived Cellulose Scaffolds for 3D Mammalian Cell Culture
Published in
PLOS ONE, May 2014
DOI 10.1371/journal.pone.0097835
Pubmed ID
Authors

Daniel J. Modulevsky, Cory Lefebvre, Kristina Haase, Zeinab Al-Rekabi, Andrew E. Pelling

Abstract

There are numerous approaches for producing natural and synthetic 3D scaffolds that support the proliferation of mammalian cells. 3D scaffolds better represent the natural cellular microenvironment and have many potential applications in vitro and in vivo. Here, we demonstrate that 3D cellulose scaffolds produced by decellularizing apple hypanthium tissue can be employed for in vitro 3D culture of NIH3T3 fibroblasts, mouse C2C12 muscle myoblasts and human HeLa epithelial cells. We show that these cells can adhere, invade and proliferate in the cellulose scaffolds. In addition, biochemical functionalization or chemical cross-linking can be employed to control the surface biochemistry and/or mechanical properties of the scaffold. The cells retain high viability even after 12 continuous weeks of culture and can achieve cell densities comparable with other natural and synthetic scaffold materials. Apple derived cellulose scaffolds are easily produced, inexpensive and originate from a renewable source. Taken together, these results demonstrate that naturally derived cellulose scaffolds offer a complementary approach to existing techniques for the in vitro culture of mammalian cells in a 3D environment.

X Demographics

X Demographics

The data shown below were collected from the profiles of 34 X users who shared this research output. Click here to find out more about how the information was compiled.
Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 486 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
United Kingdom 1 <1%
United States 1 <1%
Germany 1 <1%
Australia 1 <1%
Unknown 482 99%

Demographic breakdown

Readers by professional status Count As %
Student > Bachelor 123 25%
Student > Ph. D. Student 70 14%
Student > Master 60 12%
Researcher 46 9%
Student > Doctoral Student 15 3%
Other 47 10%
Unknown 125 26%
Readers by discipline Count As %
Biochemistry, Genetics and Molecular Biology 94 19%
Agricultural and Biological Sciences 68 14%
Engineering 61 13%
Materials Science 19 4%
Chemical Engineering 16 3%
Other 77 16%
Unknown 151 31%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 109. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 09 December 2022.
All research outputs
#379,358
of 25,119,447 outputs
Outputs from PLOS ONE
#5,378
of 217,934 outputs
Outputs of similar age
#3,229
of 233,210 outputs
Outputs of similar age from PLOS ONE
#118
of 4,728 outputs
Altmetric has tracked 25,119,447 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 98th percentile: it's in the top 5% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 217,934 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 15.7. This one has done particularly well, scoring higher than 97% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 233,210 tracked outputs that were published within six weeks on either side of this one in any source. This one has done particularly well, scoring higher than 98% of its contemporaries.
We're also able to compare this research output to 4,728 others from the same source and published within six weeks on either side of this one. This one has done particularly well, scoring higher than 97% of its contemporaries.