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Effective pulmonary delivery of an aerosolized plasmid DNA vaccine via surface acoustic wave nebulization

Overview of attention for article published in Respiratory Research, May 2014
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About this Attention Score

  • In the top 25% of all research outputs scored by Altmetric
  • High Attention Score compared to outputs of the same age (85th percentile)
  • High Attention Score compared to outputs of the same age and source (85th percentile)

Mentioned by

news
1 news outlet
twitter
2 X users
patent
1 patent
facebook
1 Facebook page

Citations

dimensions_citation
80 Dimensions

Readers on

mendeley
112 Mendeley
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Title
Effective pulmonary delivery of an aerosolized plasmid DNA vaccine via surface acoustic wave nebulization
Published in
Respiratory Research, May 2014
DOI 10.1186/1465-9921-15-60
Pubmed ID
Authors

Anushi E Rajapaksa, Jenny J Ho, Aisha Qi, Rob Bischof, Tri-Hung Nguyen, Michelle Tate, David Piedrafita, Michelle P McIntosh, Leslie Y Yeo, Els Meeusen, Ross L Coppel, James R Friend

Abstract

Pulmonary-delivered gene therapy promises to mitigate vaccine safety issues and reduce the need for needles and skilled personnel to use them. While plasmid DNA (pDNA) offers a rapid route to vaccine production without side effects or reliance on cold chain storage, its delivery to the lung has proved challenging. Conventional methods, including jet and ultrasonic nebulizers, fail to deliver large biomolecules like pDNA intact due to the shear and cavitational stresses present during nebulization.

X Demographics

X Demographics

The data shown below were collected from the profiles of 2 X users who shared this research output. Click here to find out more about how the information was compiled.
Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 112 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
United Kingdom 1 <1%
United States 1 <1%
Unknown 110 98%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 28 25%
Researcher 27 24%
Other 8 7%
Student > Bachelor 7 6%
Student > Doctoral Student 6 5%
Other 19 17%
Unknown 17 15%
Readers by discipline Count As %
Engineering 30 27%
Agricultural and Biological Sciences 11 10%
Pharmacology, Toxicology and Pharmaceutical Science 10 9%
Immunology and Microbiology 8 7%
Medicine and Dentistry 7 6%
Other 21 19%
Unknown 25 22%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 10. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 16 June 2022.
All research outputs
#3,415,350
of 25,374,647 outputs
Outputs from Respiratory Research
#437
of 3,062 outputs
Outputs of similar age
#32,792
of 240,001 outputs
Outputs of similar age from Respiratory Research
#5
of 34 outputs
Altmetric has tracked 25,374,647 research outputs across all sources so far. Compared to these this one has done well and is in the 86th percentile: it's in the top 25% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 3,062 research outputs from this source. They typically receive more attention than average, with a mean Attention Score of 7.9. This one has done well, scoring higher than 85% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 240,001 tracked outputs that were published within six weeks on either side of this one in any source. This one has done well, scoring higher than 85% of its contemporaries.
We're also able to compare this research output to 34 others from the same source and published within six weeks on either side of this one. This one has done well, scoring higher than 85% of its contemporaries.