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X Demographics
Mendeley readers
Attention Score in Context
| Title |
Galectin-3 drives glycosphingolipid-dependent biogenesis of clathrin-independent carriers
|
|---|---|
| Published in |
Nature Cell Biology, May 2014
|
| DOI | 10.1038/ncb2970 |
| Pubmed ID | |
| Authors |
Ramya Lakshminarayan, Christian Wunder, Ulrike Becken, Mark T. Howes, Carola Benzing, Senthil Arumugam, Susanne Sales, Nicholas Ariotti, Valérie Chambon, Christophe Lamaze, Damarys Loew, Andrej Shevchenko, Katharina Gaus, Robert G. Parton, Ludger Johannes |
| Abstract |
Several cell surface molecules including signalling receptors are internalized by clathrin-independent endocytosis. How this process is initiated, how cargo proteins are sorted and membranes are bent remains unknown. Here, we found that a carbohydrate-binding protein, galectin-3 (Gal3), triggered the glycosphingolipid (GSL)-dependent biogenesis of a morphologically distinct class of endocytic structures, termed clathrin-independent carriers (CLICs). Super-resolution and reconstitution studies showed that Gal3 required GSLs for clustering and membrane bending. Gal3 interacted with a defined set of cargo proteins. Cellular uptake of the CLIC cargo CD44 was dependent on Gal3, GSLs and branched N-glycosylation. Endocytosis of β1-integrin was also reliant on Gal3. Analysis of different galectins revealed a distinct profile of cargoes and uptake structures, suggesting the existence of different CLIC populations. We conclude that Gal3 functionally integrates carbohydrate specificity on cargo proteins with the capacity of GSLs to drive clathrin-independent plasma membrane bending as a first step of CLIC biogenesis. |
X Demographics
The data shown below were collected from the profile of 1 X user who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United Kingdom | 1 | 100% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 1 | 100% |
Mendeley readers
The data shown below were compiled from readership statistics for 281 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United Kingdom | 3 | 1% |
| Portugal | 1 | <1% |
| Netherlands | 1 | <1% |
| Sweden | 1 | <1% |
| China | 1 | <1% |
| Japan | 1 | <1% |
| United States | 1 | <1% |
| Unknown | 272 | 97% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 73 | 26% |
| Researcher | 60 | 21% |
| Student > Master | 26 | 9% |
| Student > Bachelor | 17 | 6% |
| Student > Doctoral Student | 16 | 6% |
| Other | 42 | 15% |
| Unknown | 47 | 17% |
| Readers by discipline | Count | As % |
|---|---|---|
| Agricultural and Biological Sciences | 93 | 33% |
| Biochemistry, Genetics and Molecular Biology | 65 | 23% |
| Medicine and Dentistry | 17 | 6% |
| Chemistry | 14 | 5% |
| Neuroscience | 10 | 4% |
| Other | 28 | 10% |
| Unknown | 54 | 19% |
Attention Score in Context
This research output has an Altmetric Attention Score of 5. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 16 June 2021.
All research outputs
#5,872,424
of 22,756,196 outputs
Outputs from Nature Cell Biology
#2,123
of 3,818 outputs
Outputs of similar age
#55,238
of 227,373 outputs
Outputs of similar age from Nature Cell Biology
#30
of 56 outputs
Altmetric has tracked 22,756,196 research outputs across all sources so far. This one has received more attention than most of these and is in the 73rd percentile.
So far Altmetric has tracked 3,818 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 21.0. This one is in the 43rd percentile – i.e., 43% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 227,373 tracked outputs that were published within six weeks on either side of this one in any source. This one has done well, scoring higher than 75% of its contemporaries.
We're also able to compare this research output to 56 others from the same source and published within six weeks on either side of this one. This one is in the 46th percentile – i.e., 46% of its contemporaries scored the same or lower than it.