| Title |
Neuroanatomic changes and their association with cognitive decline in mild cognitive impairment: a meta-analysis
|
|---|---|
| Published in |
Brain Structure and Function, June 2011
|
| DOI | 10.1007/s00429-011-0333-x |
| Pubmed ID | |
| Authors |
Thomas Nickl-Jockschat, Alexandra Kleiman, Jörg B. Schulz, Frank Schneider, Angela R. Laird, Peter T. Fox, Simon B. Eickhoff, Kathrin Reetz |
| Abstract |
Mild cognitive impairment (MCI) is an acquired syndrome characterised by cognitive decline not affecting activities of daily living. Using a quantitative meta-analytic approach, we aimed to identify consistent neuroanatomic correlates of MCI and how they are related to cognitive dysfunction. The meta-analysis enrols 22 studies, involving 917 MCI (848 amnestic MCI) patients and 809 healthy controls. Only studies investigating local changes in grey matter and reporting whole-brain results in stereotactic coordinates were included and analysed using the activation likelihood estimation approach. Probabilistic cytoarchitectonic maps were used to compare the localization of the obtained significant effects to histological areas. A correlation between the probability of grey matter changes and cognitive performance of MCI patients was performed. In MCI patients, the meta-analysis revealed three significant clusters of convergent grey matter atrophy, which were mainly situated in the bilateral amygdala and hippocampus, extending to the left medial temporal pole and thalamus, as well as in the bilateral precuneus. A sub-analysis in only amnestic MCI revealed a similar pattern. A voxel-wise analysis revealed a correlation between grey matter reduction and cognitive decline in the right hippocampus and amygdala as well as in the left thalamus. This study provides convergent evidence of a distinct neuroanatomical pattern in MCI. The correlation analysis with cognitive-mnestic decline further highlights the impact of limbic structures and the linkage with data from a functional neuroimaging database provides additional insight into underlying functions. Although different pathologies are underlying MCI, the observed neuroanatomical pattern of structural changes may reflect the common clinical denominator of cognitive impairment. |
X Demographics
The data shown below were collected from the profile of 1 X user who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 1 | 100% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Practitioners (doctors, other healthcare professionals) | 1 | 100% |
Mendeley readers
The data shown below were compiled from readership statistics for 110 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 2 | 2% |
| Ireland | 1 | <1% |
| Netherlands | 1 | <1% |
| Austria | 1 | <1% |
| Italy | 1 | <1% |
| Unknown | 104 | 95% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 16 | 15% |
| Researcher | 12 | 11% |
| Student > Master | 11 | 10% |
| Student > Doctoral Student | 11 | 10% |
| Other | 9 | 8% |
| Other | 21 | 19% |
| Unknown | 30 | 27% |
| Readers by discipline | Count | As % |
|---|---|---|
| Psychology | 26 | 24% |
| Medicine and Dentistry | 14 | 13% |
| Neuroscience | 14 | 13% |
| Agricultural and Biological Sciences | 8 | 7% |
| Biochemistry, Genetics and Molecular Biology | 3 | 3% |
| Other | 7 | 6% |
| Unknown | 38 | 35% |
Attention Score in Context
This research output has an Altmetric Attention Score of 2. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 19 March 2012.
All research outputs
#15,270,937
of 24,217,893 outputs
Outputs from Brain Structure and Function
#873
of 1,725 outputs
Outputs of similar age
#83,301
of 116,454 outputs
Outputs of similar age from Brain Structure and Function
#1
of 4 outputs
Altmetric has tracked 24,217,893 research outputs across all sources so far. This one is in the 34th percentile – i.e., 34% of other outputs scored the same or lower than it.
So far Altmetric has tracked 1,725 research outputs from this source. They typically receive a little more attention than average, with a mean Attention Score of 7.0. This one is in the 44th percentile – i.e., 44% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 116,454 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 26th percentile – i.e., 26% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 4 others from the same source and published within six weeks on either side of this one. This one has scored higher than all of them