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The ctenophore genome and the evolutionary origins of neural systems

Overview of attention for article published in Nature, May 2014
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  • In the top 5% of all research outputs scored by Altmetric
  • High Attention Score compared to outputs of the same age (99th percentile)
  • High Attention Score compared to outputs of the same age and source (96th percentile)

Citations

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620 Dimensions

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1078 Mendeley
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5 CiteULike
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Title
The ctenophore genome and the evolutionary origins of neural systems
Published in
Nature, May 2014
DOI 10.1038/nature13400
Pubmed ID
Authors

Leonid L. Moroz, Kevin M. Kocot, Mathew R. Citarella, Sohn Dosung, Tigran P. Norekian, Inna S. Povolotskaya, Anastasia P. Grigorenko, Christopher Dailey, Eugene Berezikov, Katherine M. Buckley, Andrey Ptitsyn, Denis Reshetov, Krishanu Mukherjee, Tatiana P. Moroz, Yelena Bobkova, Fahong Yu, Vladimir V. Kapitonov, Jerzy Jurka, Yuri V. Bobkov, Joshua J. Swore, David O. Girardo, Alexander Fodor, Fedor Gusev, Rachel Sanford, Rebecca Bruders, Ellen Kittler, Claudia E. Mills, Jonathan P. Rast, Romain Derelle, Victor V. Solovyev, Fyodor A. Kondrashov, Billie J. Swalla, Jonathan V. Sweedler, Evgeny I. Rogaev, Kenneth M. Halanych, Andrea B. Kohn

Abstract

The origins of neural systems remain unresolved. In contrast to other basal metazoans, ctenophores (comb jellies) have both complex nervous and mesoderm-derived muscular systems. These holoplanktonic predators also have sophisticated ciliated locomotion, behaviour and distinct development. Here we present the draft genome of Pleurobrachia bachei, Pacific sea gooseberry, together with ten other ctenophore transcriptomes, and show that they are remarkably distinct from other animal genomes in their content of neurogenic, immune and developmental genes. Our integrative analyses place Ctenophora as the earliest lineage within Metazoa. This hypothesis is supported by comparative analysis of multiple gene families, including the apparent absence of HOX genes, canonical microRNA machinery, and reduced immune complement in ctenophores. Although two distinct nervous systems are well recognized in ctenophores, many bilaterian neuron-specific genes and genes of 'classical' neurotransmitter pathways either are absent or, if present, are not expressed in neurons. Our metabolomic and physiological data are consistent with the hypothesis that ctenophore neural systems, and possibly muscle specification, evolved independently from those in other animals.

X Demographics

X Demographics

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Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 1,078 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
United States 29 3%
Brazil 7 <1%
Japan 5 <1%
United Kingdom 5 <1%
Portugal 4 <1%
France 4 <1%
Germany 4 <1%
Spain 3 <1%
Canada 3 <1%
Other 21 2%
Unknown 993 92%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 258 24%
Researcher 187 17%
Student > Bachelor 143 13%
Student > Master 126 12%
Professor 62 6%
Other 180 17%
Unknown 122 11%
Readers by discipline Count As %
Agricultural and Biological Sciences 537 50%
Biochemistry, Genetics and Molecular Biology 199 18%
Neuroscience 69 6%
Environmental Science 24 2%
Medicine and Dentistry 17 2%
Other 93 9%
Unknown 139 13%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 423. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 28 December 2023.
All research outputs
#68,910
of 25,584,565 outputs
Outputs from Nature
#5,241
of 98,303 outputs
Outputs of similar age
#481
of 240,370 outputs
Outputs of similar age from Nature
#37
of 1,005 outputs
Altmetric has tracked 25,584,565 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 99th percentile: it's in the top 5% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 98,303 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 102.6. This one has done particularly well, scoring higher than 94% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 240,370 tracked outputs that were published within six weeks on either side of this one in any source. This one has done particularly well, scoring higher than 99% of its contemporaries.
We're also able to compare this research output to 1,005 others from the same source and published within six weeks on either side of this one. This one has done particularly well, scoring higher than 96% of its contemporaries.