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A block to pre-prepared movement in gait freezing, relieved by pedunculopontine nucleus stimulation

Overview of attention for article published in Brain, June 2011
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Title
A block to pre-prepared movement in gait freezing, relieved by pedunculopontine nucleus stimulation
Published in
Brain, June 2011
DOI 10.1093/brain/awr131
Pubmed ID
Authors

Wesley Thevathasan, Alek Pogosyan, Jonathan A. Hyam, Ned Jenkinson, Marko Bogdanovic, Terry J. Coyne, Peter A. Silburn, Tipu Z. Aziz, Peter Brown

Abstract

Gait freezing and postural instability are disabling features of Parkinsonian disorders, treatable with pedunculopontine nucleus stimulation. Both features are considered deficits of proximal and axial musculature, innervated predominantly by reticulospinal pathways and tend to manifest when gait and posture require adjustment. Adjustments to gait and posture are amenable to pre-preparation and rapid triggered release. Experimentally, such accelerated release can be elicited by loud auditory stimuli--a phenomenon known as 'StartReact'. We observed StartReact in healthy and Parkinsonian controls. However, StartReact was absent in Parkinsonian patients with severe gait freezing and postural instability. Pedunculopontine nucleus stimulation restored StartReact proximally and proximal reaction times to loud stimuli correlated with gait and postural disturbance. These findings suggest a relative block to triggered, pre-prepared movement in gait freezing and postural instability, relieved by pedunculopontine nucleus stimulation.

Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 130 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
United Kingdom 3 2%
Netherlands 1 <1%
Germany 1 <1%
Australia 1 <1%
Belgium 1 <1%
Unknown 123 95%

Demographic breakdown

Readers by professional status Count As %
Researcher 29 22%
Student > Ph. D. Student 17 13%
Student > Master 15 12%
Student > Bachelor 10 8%
Professor > Associate Professor 8 6%
Other 21 16%
Unknown 30 23%
Readers by discipline Count As %
Medicine and Dentistry 32 25%
Neuroscience 22 17%
Psychology 11 8%
Agricultural and Biological Sciences 8 6%
Nursing and Health Professions 7 5%
Other 17 13%
Unknown 33 25%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 22 February 2012.
All research outputs
#17,285,036
of 25,371,288 outputs
Outputs from Brain
#6,618
of 7,625 outputs
Outputs of similar age
#93,485
of 126,913 outputs
Outputs of similar age from Brain
#40
of 61 outputs
Altmetric has tracked 25,371,288 research outputs across all sources so far. This one is in the 21st percentile – i.e., 21% of other outputs scored the same or lower than it.
So far Altmetric has tracked 7,625 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 27.7. This one is in the 9th percentile – i.e., 9% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 126,913 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 16th percentile – i.e., 16% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 61 others from the same source and published within six weeks on either side of this one. This one is in the 22nd percentile – i.e., 22% of its contemporaries scored the same or lower than it.