Title |
Erythropoietin and retinopathy of prematurity: a meta-analysis
|
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Published in |
European Journal of Pediatrics, May 2014
|
DOI | 10.1007/s00431-014-2332-4 |
Pubmed ID | |
Authors |
Xu-Juan Xu, Hai-Yan Huang, Hong-Lin Chen |
Abstract |
We performed a meta-analysis to study the association between erythropoietin (EPO) and the development of retinopathy of prematurity (ROP) in preterm newborn infants. Studies were identified through PubMed (1966-) and ISI databases (1965-) literature searches. Results and effect sizes are expressed as odds ratio (OR) with 95 % confidence intervals (CI). Fourteen studies identified to the meta-analysis, including 3,484 preterm newborn infants. A total of 563 of 1,221 babies treated with EPO had ROP (46.1 %) vs. 420 of 1,134 babies without EPO (37.0 %). No significant difference was found in the ROP risk between the two groups, with the OR 1.592 (95 % CI 0.901-2.812). A total of 192 of 1,298 babies treated with EPO had severe ROP (stage 3-4) (14.8 %) vs. 166 of 1,199 babies without EPO (13.8 %). The OR was 1.203 (95 % CI 0.763-1.896). No significant publication bias was found. Sensitivity analyses showed the results were robust. |
X Demographics
Geographical breakdown
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United Kingdom | 1 | 100% |
Demographic breakdown
Type | Count | As % |
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Members of the public | 1 | 100% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
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United States | 1 | 3% |
Unknown | 37 | 97% |
Demographic breakdown
Readers by professional status | Count | As % |
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Researcher | 7 | 18% |
Student > Postgraduate | 6 | 16% |
Student > Master | 5 | 13% |
Student > Ph. D. Student | 4 | 11% |
Student > Doctoral Student | 2 | 5% |
Other | 4 | 11% |
Unknown | 10 | 26% |
Readers by discipline | Count | As % |
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Medicine and Dentistry | 21 | 55% |
Nursing and Health Professions | 3 | 8% |
Sports and Recreations | 1 | 3% |
Veterinary Science and Veterinary Medicine | 1 | 3% |
Social Sciences | 1 | 3% |
Other | 1 | 3% |
Unknown | 10 | 26% |