Title |
Genome-wide Association Studies in Alzheimer’s Disease: A Review
|
---|---|
Published in |
Current Neurology and Neuroscience Reports, August 2013
|
DOI | 10.1007/s11910-013-0381-0 |
Pubmed ID | |
Authors |
Giuseppe Tosto, Christiane Reitz |
Abstract |
Over the past decade, research aiming to disentangle the genetic underpinnings of late-onset Alzheimer's disease has mostly focused on the identification of common variants through genome-wide association studies. The identification of several new susceptibility genes through these efforts has reinforced the importance of amyloid precursor protein and tau metabolism in the cause of the disease and has implicated immune response, inflammation, lipid metabolism, endocytosis/intracellular trafficking, and cell migration in the cause of the disease. Ongoing and future large-scale genome-wide association studies, translational studies, and next-generation whole genome or whole exome sequencing efforts, hold the promise to map the specific causative variants in these genes, to identify several additional risk variants, including rare and structural variants, and to identify novel targets for genetic testing, prevention, and treatment. |
X Demographics
Geographical breakdown
Country | Count | As % |
---|---|---|
Unknown | 1 | 100% |
Demographic breakdown
Type | Count | As % |
---|---|---|
Members of the public | 1 | 100% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
United States | 1 | 2% |
Germany | 1 | 2% |
Unknown | 50 | 96% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Student > Bachelor | 10 | 19% |
Student > Master | 10 | 19% |
Student > Ph. D. Student | 10 | 19% |
Researcher | 7 | 13% |
Professor > Associate Professor | 2 | 4% |
Other | 2 | 4% |
Unknown | 11 | 21% |
Readers by discipline | Count | As % |
---|---|---|
Biochemistry, Genetics and Molecular Biology | 12 | 23% |
Neuroscience | 9 | 17% |
Agricultural and Biological Sciences | 5 | 10% |
Pharmacology, Toxicology and Pharmaceutical Science | 4 | 8% |
Engineering | 2 | 4% |
Other | 7 | 13% |
Unknown | 13 | 25% |