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X Demographics
Mendeley readers
Attention Score in Context
| Title |
Intermittent fasting attenuates inflammasome activity in ischemic stroke
|
|---|---|
| Published in |
Experimental Neurology, May 2014
|
| DOI | 10.1016/j.expneurol.2014.04.017 |
| Pubmed ID | |
| Authors |
David Yang-Wei Fann, Tomislav Santro, Silvia Manzanero, Alexander Widiapradja, Yi-Lin Cheng, Seung-Yoon Lee, Prasad Chunduri, Dong-Gyu Jo, Alexis M. Stranahan, Mark P. Mattson, Thiruma V. Arumugam |
| Abstract |
Recent findings have revealed a novel inflammatory mechanism that contributes to tissue injury in cerebral ischemia mediated by multi-protein complexes termed inflammasomes. Intermittent fasting (IF) can decrease the levels of pro-inflammatory cytokines in the periphery and brain. Here we investigated the impact of IF (16h of food deprivation daily) for 4months on NLRP1 and NLRP3 inflammasome activities following cerebral ischemia. Ischemic stroke was induced in C57BL/6J mice by middle cerebral artery occlusion, followed by reperfusion (I/R). IF decreased the activation of NF-κB and MAPK signaling pathways, the expression of NLRP1 and NLRP3 inflammasome proteins, and both IL-1β and IL-18 in the ischemic brain tissue. These findings demonstrate that IF can attenuate the inflammatory response and tissue damage following ischemic stroke by a mechanism involving suppression of NLRP1 and NLRP3 inflammasome activity. |
X Demographics
The data shown below were collected from the profiles of 11 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Spain | 1 | 9% |
| United States | 1 | 9% |
| Unknown | 9 | 82% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 10 | 91% |
| Practitioners (doctors, other healthcare professionals) | 1 | 9% |
Mendeley readers
The data shown below were compiled from readership statistics for 120 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Singapore | 1 | <1% |
| Unknown | 119 | 99% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Bachelor | 28 | 23% |
| Student > Ph. D. Student | 20 | 17% |
| Researcher | 13 | 11% |
| Student > Master | 11 | 9% |
| Student > Postgraduate | 6 | 5% |
| Other | 24 | 20% |
| Unknown | 18 | 15% |
| Readers by discipline | Count | As % |
|---|---|---|
| Agricultural and Biological Sciences | 19 | 16% |
| Medicine and Dentistry | 18 | 15% |
| Neuroscience | 13 | 11% |
| Biochemistry, Genetics and Molecular Biology | 11 | 9% |
| Nursing and Health Professions | 7 | 6% |
| Other | 26 | 22% |
| Unknown | 26 | 22% |
Attention Score in Context
This research output has an Altmetric Attention Score of 19. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 04 April 2023.
All research outputs
#1,936,951
of 25,497,142 outputs
Outputs from Experimental Neurology
#112
of 3,973 outputs
Outputs of similar age
#18,996
of 242,084 outputs
Outputs of similar age from Experimental Neurology
#3
of 43 outputs
Altmetric has tracked 25,497,142 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 92nd percentile: it's in the top 10% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 3,973 research outputs from this source. They typically receive a little more attention than average, with a mean Attention Score of 5.3. This one has done particularly well, scoring higher than 97% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 242,084 tracked outputs that were published within six weeks on either side of this one in any source. This one has done particularly well, scoring higher than 92% of its contemporaries.
We're also able to compare this research output to 43 others from the same source and published within six weeks on either side of this one. This one has done particularly well, scoring higher than 95% of its contemporaries.