| Title |
The incidence of and risk factors for developing atypical femoral fractures in Japan
|
|---|---|
| Published in |
Journal of Bone and Mineral Metabolism, May 2014
|
| DOI | 10.1007/s00774-014-0591-9 |
| Pubmed ID | |
| Authors |
Yoshitomo Saita, Muneaki Ishijima, Atsuhiko Mogami, Mitsuaki Kubota, Tomonori Baba, Takefumi Kaketa, Masashi Nagao, Yuko Sakamoto, Kensuke Sakai, Yasuhiro Homma, Rui Kato, Nana Nagura, Kei Miyagawa, Tomoki Wada, Lizu Liu, Joe Matsuoka, Osamu Obayashi, Katsuo Shitoto, Masahiko Nozawa, Hajime Kajihara, Hogaku Gen, Kazuo Kaneko |
| Abstract |
The long-term treatment with anti-resorptive drugs for osteoporotic patients is suggested to be associated with an increase in atypical femoral fractures (AFFs). However, their incidence, patient characteristics, and risk factors have not been fully elucidated especially in Asian countries. This retrospective observational cohort study found fourteen AFFs in ten patients (four bilateral fractures) among 2,238 hip and femoral shaft fractures treated in our associated hospitals between 2005 and 2010; this incidence (0.63 %) was similar to Caucasians. Of the ten patients with AFFs, nine (90 %) and six (60 %) were using bisphosphonates (BPs) and glucocorticoids (GCs), respectively, compared to 14.3 and 8.6 % for patients with typical femoral fractures who were using these agents. As comorbid conditions, five patients had collagen disease (CD) and two had diabetes. A fracture location-, age- and gender-matched (1:3) case-control study revealed that administration of BPs, GCs, and suffering from collagen disease (CD) were significant risk factors for developing AFFs [odds ratios 36.0 (95 % confidence intervals 3.8-342.2), 13.0 (2.3-74.1) and 9.0 (1.6-50.3), respectively]. Interestingly, all of the patients with atypical subtrochanteric femoral fractures, defined as those within 5 cm of the lesser trochanter, were taking GCs due to CD, and the age of these patients (average of 54.8 years) was significantly younger than those with atypical diaphyseal femoral fractures (average of 77.2 years, p < 0.05). In conclusion, the incidence of AFFs in the Japanese population was similar to that of Caucasians, and taking BPs and GCs and suffering from CD were risk factors for developing AFFs. |
X Demographics
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Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 1 | 100% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 1 | 100% |
Mendeley readers
The data shown below were compiled from readership statistics for 34 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 34 | 100% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Researcher | 6 | 18% |
| Student > Ph. D. Student | 4 | 12% |
| Student > Doctoral Student | 4 | 12% |
| Professor > Associate Professor | 4 | 12% |
| Student > Master | 4 | 12% |
| Other | 11 | 32% |
| Unknown | 1 | 3% |
| Readers by discipline | Count | As % |
|---|---|---|
| Medicine and Dentistry | 20 | 59% |
| Pharmacology, Toxicology and Pharmaceutical Science | 3 | 9% |
| Biochemistry, Genetics and Molecular Biology | 2 | 6% |
| Unspecified | 1 | 3% |
| Psychology | 1 | 3% |
| Other | 3 | 9% |
| Unknown | 4 | 12% |
Attention Score in Context
This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 22 May 2014.
All research outputs
#21,180,380
of 23,842,189 outputs
Outputs from Journal of Bone and Mineral Metabolism
#563
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#194,355
of 228,300 outputs
Outputs of similar age from Journal of Bone and Mineral Metabolism
#13
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