| Title |
Toll-like receptors and B cells: functions and mechanisms
|
|---|---|
| Published in |
Immunologic Research, May 2014
|
| DOI | 10.1007/s12026-014-8523-2 |
| Pubmed ID | |
| Authors |
Claire M. Buchta, Gail A. Bishop |
| Abstract |
Numerous reports have described Toll-like receptor (TLR) functions in myeloid cells such as dendritic cells (DCs) and macrophages, but relatively fewer studies have examined TLR responses in B lymphocytes. B cells express a wide variety of TLRs and are highly activated after TLR ligation, leading to enhancements in B cell survival, surface molecule expression, cytokine and antibody production, and antigen presentation. During an immune response, B cells can receive signals through TLRs as well as the B cell antigen receptor (BCR) and/or CD40. TLR ligation synergizes with signals through these receptors and augments both innate and adaptive immune functions of B lymphocytes. Additionally, targeting B cell TLRs may provide new therapies against certain types of cancer as well as autoimmune diseases. Here, we summarize TLR expression and contributions to both normal and pathogenic functions in mouse and human B cells. |
X Demographics
The data shown below were collected from the profiles of 3 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Ecuador | 1 | 33% |
| United Kingdom | 1 | 33% |
| Unknown | 1 | 33% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 2 | 67% |
| Science communicators (journalists, bloggers, editors) | 1 | 33% |
Mendeley readers
The data shown below were compiled from readership statistics for 119 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 119 | 100% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 30 | 25% |
| Researcher | 20 | 17% |
| Student > Bachelor | 16 | 13% |
| Student > Master | 11 | 9% |
| Student > Doctoral Student | 5 | 4% |
| Other | 11 | 9% |
| Unknown | 26 | 22% |
| Readers by discipline | Count | As % |
|---|---|---|
| Agricultural and Biological Sciences | 25 | 21% |
| Immunology and Microbiology | 19 | 16% |
| Biochemistry, Genetics and Molecular Biology | 18 | 15% |
| Medicine and Dentistry | 16 | 13% |
| Pharmacology, Toxicology and Pharmaceutical Science | 3 | 3% |
| Other | 10 | 8% |
| Unknown | 28 | 24% |
Attention Score in Context
This research output has an Altmetric Attention Score of 2. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 03 September 2014.
All research outputs
#13,915,695
of 22,756,196 outputs
Outputs from Immunologic Research
#510
of 901 outputs
Outputs of similar age
#116,060
of 226,264 outputs
Outputs of similar age from Immunologic Research
#18
of 33 outputs
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