| Title |
Hepatitis B virus X gene and hepatocarcinogenesis
|
|---|---|
| Published in |
Journal of Gastroenterology, June 2011
|
| DOI | 10.1007/s00535-011-0415-9 |
| Pubmed ID | |
| Authors |
Sue-Ann Ng, Caroline Lee |
| Abstract |
Chronic hepatitis B virus (HBV) infection has been identified as a major risk factor in hepatocellular carcinoma (HCC), which is one of the most common cancers worldwide. The pathogenesis of HBV-mediated hepatocarcinogenesis is, however, incompletely understood. Evidence suggests that the HBV X protein (HBx) plays a crucial role in HCC development. HBx is a multifunctional regulator that modulates transcription, signal transduction, cell cycle progression, apoptosis, protein degradation pathways, and genetic stability through interaction with host factors. This review describes the current state of knowledge of the molecular pathogenesis of HBV-induced HCC, with a focus on the role of HBx in hepatocarcinogenesis. |
X Demographics
The data shown below were collected from the profile of 1 X user who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 1 | 100% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 1 | 100% |
Mendeley readers
The data shown below were compiled from readership statistics for 91 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Germany | 1 | 1% |
| South Africa | 1 | 1% |
| Russia | 1 | 1% |
| Spain | 1 | 1% |
| United States | 1 | 1% |
| Unknown | 86 | 95% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Researcher | 24 | 26% |
| Student > Ph. D. Student | 13 | 14% |
| Student > Master | 7 | 8% |
| Student > Bachelor | 6 | 7% |
| Student > Doctoral Student | 4 | 4% |
| Other | 18 | 20% |
| Unknown | 19 | 21% |
| Readers by discipline | Count | As % |
|---|---|---|
| Agricultural and Biological Sciences | 30 | 33% |
| Medicine and Dentistry | 15 | 16% |
| Biochemistry, Genetics and Molecular Biology | 13 | 14% |
| Unspecified | 4 | 4% |
| Pharmacology, Toxicology and Pharmaceutical Science | 2 | 2% |
| Other | 9 | 10% |
| Unknown | 18 | 20% |
Attention Score in Context
This research output has an Altmetric Attention Score of 4. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 27 December 2022.
All research outputs
#6,626,022
of 23,420,064 outputs
Outputs from Journal of Gastroenterology
#263
of 1,113 outputs
Outputs of similar age
#35,773
of 113,909 outputs
Outputs of similar age from Journal of Gastroenterology
#1
of 7 outputs
Altmetric has tracked 23,420,064 research outputs across all sources so far. This one has received more attention than most of these and is in the 70th percentile.
So far Altmetric has tracked 1,113 research outputs from this source. They receive a mean Attention Score of 5.0. This one has done well, scoring higher than 75% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 113,909 tracked outputs that were published within six weeks on either side of this one in any source. This one has gotten more attention than average, scoring higher than 66% of its contemporaries.
We're also able to compare this research output to 7 others from the same source and published within six weeks on either side of this one. This one has scored higher than all of them