Title |
Interactions Between NS1 of Influenza A Viruses and Interferon-α/β: Determinants for Vaccine Development
|
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Published in |
Journal of Interferon & Cytokine Research, May 2017
|
DOI | 10.1089/jir.2017.0032 |
Pubmed ID | |
Authors |
Ben X. Wang, Eleanor N. Fish |
Abstract |
Influenza A viruses (IAVs) cause mild to severe infections in humans with considerable socioeconomic and global health consequences. The host interferon (IFN)-α/β response, critical as the first line of defense against foreign pathogens, is induced upon detection of IAV genomic RNA in infected cells by host innate pattern recognition receptors. IFN-α/β production and subsequent activation of cell signaling result in the expression of antiviral IFN-stimulated genes whose products target various stages of the IAV life cycle to inhibit viral replication and the spread of infection and establish an antiviral state. IAVs, however, encode a multifunctional virulence factor, nonstructural protein 1 (NS1), that directly antagonizes the host IFN-α/β response to support viral replication. In this review, we highlight the mechanisms by which NS1 suppresses IFN-α/β production and subsequent cell signaling, and consider, therefore, the potential for recombinant IAVs lacking NS1 to be used as live-attenuated vaccines. |
X Demographics
Geographical breakdown
Country | Count | As % |
---|---|---|
Canada | 1 | 50% |
United States | 1 | 50% |
Demographic breakdown
Type | Count | As % |
---|---|---|
Members of the public | 2 | 100% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
Unknown | 26 | 100% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Student > Master | 6 | 23% |
Student > Ph. D. Student | 6 | 23% |
Student > Bachelor | 3 | 12% |
Student > Postgraduate | 2 | 8% |
Researcher | 2 | 8% |
Other | 1 | 4% |
Unknown | 6 | 23% |
Readers by discipline | Count | As % |
---|---|---|
Biochemistry, Genetics and Molecular Biology | 6 | 23% |
Immunology and Microbiology | 6 | 23% |
Agricultural and Biological Sciences | 3 | 12% |
Medicine and Dentistry | 2 | 8% |
Environmental Science | 1 | 4% |
Other | 2 | 8% |
Unknown | 6 | 23% |